Evidence map›Paper›PMID 39459932›Full record

ArticleViruses2024

Higher Frequency of SARS-CoV-2 RNA Shedding by Cats than Dogs in Households with Owners Recently Diagnosed with COVID-19.

Michele Lunardi, Felippe Danyel Cardoso Martins, Emanuele Gustani-Buss, Roberta Torres Chideroli, Isabela Medeiros de Oliveira, Kamila Chagas Peronni, David Livingstone Alves Figueiredo, Alice Fernandes Alfieri, Amauri Alcindo Alfieri

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michele LunardiLaboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.ORCID 0000-0002-4763-0187
Felippe Danyel Cardoso MartinsMulti-User Animal Health Laboratory, Molecular Biology Unit, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.
Emanuele Gustani-BussDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven-University of Leuven, Box 1030, 3000 Leuven, Belgium.ORCID 0000-0003-4020-3921
Roberta Torres ChideroliPost Graduate Program in Animal Science, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.ORCID 0000-0002-0271-9612
Isabela Medeiros de OliveiraInstitute for Cancer Research, IPEC, Guarapuava 85100-000, Brazil.
Kamila Chagas PeronniInstitute for Cancer Research, IPEC, Guarapuava 85100-000, Brazil.
David Livingstone Alves FigueiredoInstitute for Cancer Research, IPEC, Guarapuava 85100-000, Brazil.ORCID 0000-0002-5446-296X
Alice Fernandes AlfieriLaboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.
Amauri Alcindo AlfieriLaboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina 86057-970, Brazil.ORCID 0000-0002-7024-4487

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível SuperiorEU Horizon 2020 grants MOOD H2020-347 874850Financiadora de Estudos e ProjetosFundação Araucária PI004/2021 - protocol 17,521,506-9National Council for Scientific and Technological Development
6 · The paper itself

Abstract

Studies have demonstrated the susceptibility of companion animals to natural infection with SARS-CoV-2. Using quantitative reverse transcription polymerase chain reaction and sequencing analyses, this study investigated SARS-CoV-2 RNA excretion in pets in households with infected owners. Oropharyngeal and rectal swabs were collected from dogs and cats in Parana, Southern Brazil, between October 2020 and April 2021. Viral RNA was detected in 25% of cats and 0.98% of dog oropharyngeal swabs; however, systemic, respiratory, and gastrointestinal signs were absent. Complete viral genomes belonged to the Gamma lineage. Phylogenetic analyses indicated that pet samples were probably derived from human-positive cases in Parana. Viral excretion in the oropharynx was more frequent in cats than in dogs. Mutations in the S protein characteristic of Gamma strains were present in all sequenced SARS-CoV-2 strains. The receptor-binding domain of these Brazilian strains did not show any additional mutations not reported in the Gamma strains. Mutations in NSP6, NSP12, and N proteins previously mapped to strains that infect deer or minks were detected. This study highlights the importance of actively monitoring the SARS-CoV-2 strains that infect pets with continued viral exposure. Monitoring genetic changes is crucial because new variants adapted to animals may pose human health risks.

Indexed as

Cat DiseasesCOVID-19Dog DiseasesPhylogenyRNA, ViralSARS-CoV-2Virus SheddingAnimalsBrazilCatsDogsFamily CharacteristicsGenome, ViralHumansMutationOropharynxRNA, ViralSpike Glycoprotein, Coronaviruscoronavirusnext generation sequencingone healthpetsRT-qPCRsevere acute respiratory syndrome coronavirus 2zoonoses

Identifiers

PMID39459932
PMCPMC11512312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.