Evidence map›Paper›PMID 39459929›Full record

ArticleViruses2024

Structure and Antigenicity of the Porcine Astrovirus 4 Capsid Spike.

Danielle J Haley, Sarah Lanning, Kyle E Henricson, Andre A Mardirossian, Iyan Cirillo, Michael C Rahe, Rebecca M DuBois

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Danielle J HaleyDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0002-3980-6445
Sarah LanningDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Kyle E HenricsonDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0009-0007-5071-0181
Andre A MardirossianDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Iyan CirilloDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Michael C RaheDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0003-2123-4124
Rebecca M DuBoisDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0003-4185-5673

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Training Program in Molecular, Cell, and Developmental BiologyT32GM133391 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Needhi Bhalla · 2019 to 2026
$3.0M
Structural, mechanistic, and antigenic insights into the human astrovirus capsidR01AI144090 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI DUBOIS, REBECCA MICHELLE · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI144090NIGMS NIH HHS P30 GM124169NIGMS NIH HHS T32 GM133391NIH HHS R01AI144090Swine Health Information Center 23-077
6 · The paper itself

Abstract

Porcine astrovirus 4 (PoAstV4) has been recently associated with respiratory disease in pigs. In order to understand the scope of PoAstV4 infections and to support the development of a vaccine to combat PoAstV4 disease in pigs, we designed and produced a recombinant PoAstV4 capsid spike protein for use as an antigen in serological assays and for potential future use as a vaccine antigen. Structural prediction of the full-length PoAstV4 capsid protein guided the design of the recombinant PoAstV4 capsid spike domain expression plasmid. The recombinant PoAstV4 capsid spike was expressed in

Indexed as

Antibodies, ViralCapsid ProteinsSwine DiseasesAnimalsAntigens, ViralAstroviridae InfectionsCapsidEpitopesMamastrovirusModels, MolecularProtein ConformationRecombinant ProteinsSwineViral VaccinesAntibodies, ViralAntigens, ViralCapsid ProteinsEpitopesRecombinant ProteinsViral Vaccinesastrovirusescapsidporcine astrovirusspikevirus structure

Identifiers

PMID39459929
PMCPMC11512355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.