Evidence map›Paper›PMID 39459921›Full record

ArticleViruses2024

Assessment of PPMV-1 Genotype VI Virulence in Pigeons and Chickens and Protective Effectiveness of Paramyxovirus Vaccines in Pigeons.

Esraa E Hamouda, Amal A M Eid, Hagar F Gouda, Amina A Dessouki, Ayman H El-Deeb, Rebecca Daines, Munir Iqbal, Reham M ElBakrey

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Esraa E HamoudaAvian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
Amal A M EidAvian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.ORCID 0000-0003-4183-4899
Hagar F GoudaAnimal Wealth Development Department (Biostatistics Subdivision), Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
Amina A DessoukiPathology Department, Faculty of Veterinary Medicine, Suez Canal University, Suez Canal, Ismailia 41622, Egypt.
Ayman H El-DeebVirology Department, Faculty of Veterinary Medicine, Cairo University, Giza 11361, Egypt.
Rebecca DainesAvian Influenza and Newcastle Disease Group, The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.ORCID 0009-0001-3537-9773
Munir IqbalAvian Influenza and Newcastle Disease Group, The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.ORCID 0000-0001-5165-5339
Reham M ElBakreyAvian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.ORCID 0000-0002-8814-058X

Funding

Biotechnology and Biological Sciences Research Council BBS/E/PI/230001ABiotechnology and Biological Sciences Research Council BBS/E/PI/230001A, BBS/E/PI/230001C, BBS/E/PI/230002BBiotechnology and Biological Sciences Research Council BBS/E/PI/230001CBiotechnology and Biological Sciences Research Council BBS/E/PI/230002BNewton Mosharafa and British Council Newton Fund Institutional Links grant #IL3261727271
6 · The paper itself

Abstract

Pigeon paramyxovirus serotype 1 (PPMV-1), an antigenic and host variant of avian paramyxovirus Newcastle disease virus (NDV), primarily originating from racing pigeons, has become a global panzootic. Egypt uses both inactivated PPMV-1 and conventional NDV vaccines to protect pigeons from disease and mortality. However, the impact of prevalent strains and the effectiveness of available vaccines in pigeons in Egypt are unclear. This study investigates the virulence of PPMV-1 (Pigeon/Egypt/Sharkia-19/2015/KX580988) and evaluates available paramyxovirus vaccines in protecting pigeons against a PPMV-1 challenge. Ten-day-old specific-pathogen-free (SPF) embryonated chicken eggs infected with this strain exhibited a mean death time (MDT) of 86.4 ± 5.88 h. The intracerebral pathogenicity index (ICPI) in day-old chickens was 0.8, while pigeons experienced an ICPI of 0.96 and an intravenous pathogenicity index (IVPI) of 2.11. These findings classify the strain as virulent and velogenic. Experimental infection of pigeons with this PPMV-1 strain at 10

Indexed as

ChickensColumbidaeGenotypeNewcastle DiseaseNewcastle disease virusViral VaccinesAnimalsAntibodies, ViralEgyptPoultry DiseasesSpecific Pathogen-Free OrganismsVaccines, InactivatedVirulenceVirus SheddingAntibodies, ViralVaccines, InactivatedViral Vaccineshistopathologyimmunohistochemistrypathogenicitypigeon paramyxovirus serotype 1vaccine efficacy

Identifiers

PMID39459921
PMCPMC11512342

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.