ArticleViruses2024
Full Genome Characterization of the First Oropouche Virus Isolate Imported in Europe from Cuba.
Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Oropouche virus infection: clinical spectrum, geographic expansion, and emerging maternal-fetal implications.Infection · 2026Review
- Oropouche virus causes severe congenital disease in embryonic mice.Nature communications · 2026Article
- Oropouche Virus: Comparative Study of Two Strains Reveals Distinct Innate Immunity Modulation.Viruses · 2026Article
- Phylogeographic dynamics of oropouche virus in the Colombian Amazon: Evolutionary insights in a climatic context.PLoS neglected tropical diseases · 2026Article
- Spatiotemporal diffusion of the 2024 Oropouche outbreak in Cuba.Nature medicine · 2026Article
- Epidemiological and genomic features of chikungunya virus disease in travellers returning from Cuba, September 2025 to January 2026: a GeoSentinel analysis.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery.Cell reports. Medicine · 2026Article
- Oropouche Virus (OROV) Vaccine Development for Vulnerable Populations: Epidemiological Context, Challenges and Future Directions.Vaccines · 2026Review
- Article
- Neural cells are susceptible to historic and recently emerged Oropouche virus strains.PLoS pathogens · 2026Article
- Enhanced virulence and neuroinvasion of contemporaryFrontiers in microbiology · 2026Article
- Article
- Low risk of transmission of prototype and newly emerged Oropouche virus strains by European Culex pipiens, Aedes albopictus, and Anopheles atroparvus mosquitoes.PLoS neglected tropical diseases · 2026Article
- Oropouche virus: molecular virological characteristics and research progress of a neglected arbovirus.Virology journal · 2025Review
- Review
- Viral Metagenomic Next-Generation Sequencing for One Health Discovery and Surveillance of (Re)Emerging Viruses: A Deep Review.International journal of molecular sciences · 2025Review
- Case series of Oropouche fever among travellers returning from Cuba to Spain, 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Phylogenomics and structural modelling feature accelerated evolution of Oropouche virus: 1955 to 2024.Virologica Sinica · 2025Article
- Assessing the vector competence of Italian Culex pipiens and Aedes albopictus mosquitoes for the re-emerging Oropouche virus.Parasites & vectors · 2025Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
On 27 May 2024, the Cuban Ministry of Health reported the first outbreak of Oropouche fever on the island. The etiologic agent, Oropouche virus (OROV), is a poorly understood arbovirus that has been known since the 1960s and represents a public health burden in Latin America. We report the whole-genome characterization of the first European OROV isolate from a returning traveler from Cuba with Oropouche fever-like symptoms. The isolate was obtained from the patient's serum; whole-genome sequencing was performed by next-generation sequencing, followed by phylogenetic analysis and genetic variability studies. The analysis showed that the most closely related sequence was from the French Guiana 2020 outbreak. Interestingly, our isolate is a reassortant virus, included in a highly supported monophyletic clade containing recent OROV cases (Brazil 2015-Colombia 2021), separated from the other four previously known genotypes. More deeply, it was found to be included in a distinct branch containing the sequences of the Brazil 2022-2024 outbreak. The reassortment event involved the S and L segments, which have high similarity with sequences belonging to a new cluster (here defined as OROV_SCDC_2024), while the M segment shows high similarity with older sequences. These results likely describe the viral strain responsible for the current outbreak in Cuba, which may also reflect the ongoing outbreak in Latin America. Further studies are needed to understand how OROV evolves towards traits that facilitate its spread and adaptation outside its original basin, and to track its spread and evolution in the European continent.
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