Evidence map›Paper›PMID 39459907›Full record

ArticleViruses2024

The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States.

Claire P Smith, Rachel M Hartman, Alexa M Kugler, Verlena Little, Owen R Baker, Tarayn A Fairlie, Reinaldo E Fernandez, Melissa B Hagen, Elvira Honie, Oliver Laeyendecker and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Claire P SmithDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0003-1069-9460
Rachel M HartmanDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-6837-4629
Alexa M KuglerDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Verlena LittleDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Owen R BakerDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0006-0728-6509
Tarayn A FairlieDivision of Coronaviruses and Other Respiratory Viruses, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.ORCID 0000-0001-9954-7185
Reinaldo E FernandezDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Melissa B HagenDivision of Coronaviruses and Other Respiratory Viruses, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Elvira HonieDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Oliver LaeyendeckerDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6429-4760
Claire M MidgleyDivision of Coronaviruses and Other Respiratory Viruses, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Dennie ParkerDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Marqia SandovalDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Saki TakahashiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Laura L HammittDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Catherine G SutcliffeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0001-8512-8326

Funding

Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
Research in practice: translating infectious disease epidemiology RIP-TIDET32AI165369 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WILLIAM J MOSS · 2022 to 2026
$1.5M
CDC HHS 75D30120C08171NIAID NIH HHS T32 AI102623NIAID NIH HHS T32 AI165369
6 · The paper itself

Abstract

SARS-CoV-2 antibody kinetics based on immunologic history is not fully understood. We analyzed anti-spike and anti-nucleocapsid antibody responses following acute infection in a cohort of Indigenous persons. The models of peak concentrations and decay rates estimated that one year after infection, participants would serorevert for anti-nucleocapsid antibodies and remain seropositive for anti-spike antibodies. The peak anti-spike concentrations were higher for individuals vaccinated prior to infection, but the decay rates were similar across immunologic status groups. Children had significantly lower peak anti-spike concentrations than adults. This study affirms the importance of continued vaccination to maintain high levels of immunity in the face of waning immunity.

Indexed as

Antibodies, ViralCOVID-19SARS-CoV-2Spike Glycoprotein, CoronavirusAdolescentAdultAntibody FormationChildChild, PreschoolFemaleHumansIndigenous PeoplesMaleMiddle AgedSouthwestern United StatesVaccinationAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antibody responseIndigenous healthSARS-CoV-2

Identifiers

PMID39459907
PMCPMC11512241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.