Evidence map›Paper›PMID 39459893›Full record

ArticleViruses2024

GPCR Inhibitors Have Antiviral Properties against JC Polyomavirus Infection.

Amanda L Sandberg, Avery C S Bond, Lucas J Bennett, Sophie E Craig, David P Winski, Lara C Kirkby, Abby R Kraemer, Kristina G Kelly, Samuel T Hess, Melissa S Maginnis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amanda L SandbergDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
Avery C S BondDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
Lucas J BennettDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
Sophie E CraigDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
David P WinskiDepartment of Physics & Astronomy, University of Maine, Orono, ME 04469, USA.
Lara C KirkbyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
Abby R KraemerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
Kristina G KellyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.
Samuel T HessGraduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA.
Melissa S MaginnisDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Regulation of Cellular Behavior in Response to Extracellular CuesP20GM144265 · NIGMS · UNIVERSITY OF MAINE ORONO · PI Benjamin L King · 2023 to 2026
$11.8M
Characterization of Viral Receptors and Signaling Networks in JC Polyomavirus InfectionR15AI144686 · NIAID · UNIVERSITY OF MAINE ORONO · PI MAGINNIS, MELISSA · 2019 to 2022
$876k
Mechanism of Interaction between Influenza Hemagglutinin and Host Cell PhosphoinositidesR15GM139070 · NIGMS · UNIVERSITY OF MAINE ORONO · PI HESS, SAMUEL T · 2020 to 2020
$428k
NIAID NIH HHS R15 AI144686NIAID NIH HHS R15AI144686NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20GM103423NIGMS NIH HHS P20 GM144265NIGMS NIH HHS P20GM144265-01A1NIGMS NIH HHS R15 GM139070NIGMS NIH HHS R15GM139070
6 · The paper itself

Abstract

JC polyomavirus (JCPyV) infects the majority of the population and initially establishes a persistent but asymptomatic infection of the kidneys. In healthy individuals, the infection remains controlled by the host immune system, but for individuals experiencing prolonged immunosuppression, the infection can reactivate and spread to the brain, where it causes progressive multifocal leukoencephalopathy (PML), which is a fatal neurodegenerative disease. Currently, there are no approved therapies to treat PML, and affected individuals suffer rapid motor weakness and cognitive deterioration. To identify novel therapeutic treatments for JCPyV infection, receptor agonists/antagonists identified in a previously published drug screen were evaluated for their antiviral properties. Seven drugs were selected and validated using infectivity assays, and the mechanism of inhibition was further explored for G protein coupled receptor (GPCR)-associated inhibitors due to the role of the GPCR 5-hydroxytryptamine 2 receptors (5-HT

Indexed as

Antiviral AgentsJC VirusReceptors, G-Protein-CoupledVirus InternalizationHumansLeukoencephalopathy, Progressive MultifocalPolyomavirus InfectionsAntiviral AgentsReceptors, G-Protein-Coupled5-HT2RscetirizineGPCR agonists/antagonistsJC polyomavirusparoxetinePMLprogressive multifocal leukoencephalopathysuper-resolution microscopyβ-arrestin

Identifiers

PMID39459893
PMCPMC11512265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.