Evidence map›Paper›PMID 39459862›Full record

ReviewViruses2024

The Assembly of HTLV-1-How Does It Differ from HIV-1?

Dominik Herrmann, Shuyu Meng, Huixin Yang, Louis M Mansky, Jamil S Saad

Abstract readReview
In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dominik HerrmannDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-7187-3357
Shuyu MengInstitute for Molecular Virology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-7951-6450
Huixin YangInstitute for Molecular Virology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0003-0539-0477
Louis M ManskyInstitute for Molecular Virology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0003-2391-1061
Jamil S SaadDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-9503-6484

Funding

Structural basis for HIV-1 Gag interactions with cellular and viral constituentsR01AI150901 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Terje Dokland · 2019 to 2026
$2.9M
Deltaretrovirus Morphology and Particle AssemblyR01GM151775 · NIGMS · UNIVERSITY OF MINNESOTA · PI JOACHIM D MUELLER, Louis M Mansky · 2024 to 2026
$1.7M
Structural Basis for HIV-1 Gag assembly and Env incorporationR37AI150901 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAD, JAMIL SUBHI · 2023 to 2024
$1.2M
Imaging of HTLV-1 by cryo-CLEMR21DE032878 · NIDCR · UNIVERSITY OF MINNESOTA · PI MANSKY, LOUIS M. · 2023 to 2024
$595k
NIAID NIH HHS R01 AI150901NIDCR NIH HHS R21 DE032878NIGMS NIH HHS R01 GM151775NIH HHS 1R01GM151775-01A1NIH HHS R21DE032878NIH HHS R37AI150901-14
6 · The paper itself

Abstract

Retroviral assembly is a highly coordinated step in the replication cycle. The process is initiated when the newly synthesized Gag and Gag-Pol polyproteins are directed to the inner leaflet of the plasma membrane (PM), where they facilitate the budding and release of immature viral particles. Extensive research over the years has provided crucial insights into the molecular determinants of this assembly step. It is established that Gag targeting and binding to the PM is mediated by interactions of the matrix (MA) domain and acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Indexed as

HIV-1Human T-lymphotropic virus 1Virus AssemblyCell MembraneGene Products, gagHumansVirus ReplicationGene Products, gagcapsid (CA)Gag polyproteinhuman immunodeficiency virus type 1 (HIV-1)human T-cell leukemia virus type 1 (HTLV-1)matrix (MA)phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)plasma membrane (PM)

Identifiers

PMID39459862
PMCPMC11512237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.