Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal.

Constance Rink, Tomas Kroupa, Siddhartha A K Datta, Alan Rein

Abstract read

In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Constance RinkHIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702, USA.

Tomas KroupaHIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-5996-9057

Siddhartha A K DattaHIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702, USA.

Alan ReinHIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-8273-546X

Funding

Research supported by Intramural Research Program, Center for Cancer Research, National Cancer Institute N.A.

6 · The paper itself

Abstract

During HIV-1 virus assembly, the genomic RNA (vRNA) is selected for packaging by the viral protein Gag because it contains a specific packaging signal, Psi. While there have been numerous studies of Gag-Psi interactions, there is almost no information on the kinetic aspects of this interaction. We investigated the kinetics of Gag binding to different RNAs using switchSENSE DRX

Indexed as

gag Gene Products, Human Immunodeficiency VirusHIV-1Protein BindingRNA, ViralVirus AssemblyBinding SitesHumansKineticsNucleic Acid ConformationViral Genome Packaginggag Gene Products, Human Immunodeficiency VirusRNA, Viralbinding kineticsHIV-1packaging signalprotein–RNA interactionsPsi

Identifiers

PMID39459852

DOI10.3390/v16101517

PMCPMC11512386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.