Evidence map›Paper›PMID 39459638›Full record

ArticleLife (Basel, Switzerland)2024

Short Lysine-Containing Tripeptide as Analgesic Substance: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel.

Vera B Plakhova, Arina D Kalinina, Nadezhda A Boichenko, Dmitriy M Samosvat, Georgy G Zegrya, Irina P Butkevich, Viktor A Mikhailenko, Valentina A Penniyaynen, Svetlana A Podzorova, Roza I Yagudina and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Short Cationic ACTH-Related Peptides Can Modulate the NaInternational journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vera B PlakhovaPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.ORCID 0000-0002-1983-852X
Arina D KalininaPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.ORCID 0000-0002-8893-8049
Nadezhda A BoichenkoPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
Dmitriy M SamosvatIoffe Institute, Russian Academy of Sciences, 194021 Saint Petersburg, Russia.
Georgy G ZegryaPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
Irina P ButkevichPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
Viktor A MikhailenkoPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
Valentina A PenniyaynenPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.ORCID 0000-0003-3936-8681
Svetlana A PodzorovaPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
Roza I YagudinaDepartment of Organization of Medical Provision and Pharmacoeconomics, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.ORCID 0000-0002-9080-332X
Boris V KrylovPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
Ilya V RogachevskiiPavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.ORCID 0000-0002-8336-0604

Funding

the Ministry of Science and Higher Education of the Russian Federation № 075-15-2022-303 from 21.04.2022
6 · The paper itself

Abstract

A possible molecular mechanism of the ligand-receptor binding of Ac-Lys-Lys-Lys-NH

Indexed as

analgesicsconformational analysisdockingformalin testlysine-containing peptidesNaV1.8 channelnociceptionorganotypic tissue culture methodpatch-clamp method

Identifiers

PMID39459638
PMCPMC11509431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.