Evidence map›Paper›PMID 39459490›Full record

ArticleMedicina (Kaunas, Lithuania)2024

An Uncommon Overlap Syndrome Between Ankylosing Spondylitis and Amyotrophic Lateral Sclerosis-Case Report.

Christian Banciu, Sorin Chiriac, Cristina Pojoga, Loredana Marian, Antonio Fabian, Armand Gogulescu, Mihaela Simu, Ramona Parvanescu, Alexandra Mioc, Roxana Racoviceanu and 1 more

Abstract readCase Reports
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christian BanciuDepartment of Internal Medicine IV, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.ORCID 0009-0000-3187-3064
Sorin ChiriacDepartment of Surgery III, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
Cristina PojogaDepartment of Gastroenterology, Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania.
Loredana MarianDepartment of Rheumatology, Timiş County Emergency Clinical Hospital, 300723 Timisoara, Romania.
Antonio FabianClinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babeș Timișoara, 300310 Timisoara, Romania.
Armand GogulescuDepartment XVI: Balneology, Medical Rehabilitation and Rheumatology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.ORCID 0009-0004-4301-2279
Mihaela SimuDepartment of Neurology II, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
Ramona ParvanescuDepartment of Pharmaceutical chemistry, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
Alexandra MiocDepartment of Pharmacology-Pharmacotherapy, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
Roxana RacoviceanuDepartment of Pharmaceutical chemistry, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.ORCID 0000-0002-3378-0774
Andreea MunteanuDepartment of Internal Medicine IV, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.ORCID 0000-0002-5562-5855

Funding

"Victor Babes" University of Medicine and Pharmacy Timisoara
6 · The paper itself

Abstract

This case report describes an uncommon overlap syndrome between ankylosing spondylitis (AS) and amyotrophic lateral sclerosis (ALS). Initially, the patient was diagnosed with AS, for which he received various specific treatments, including TNF-α inhibitors. After five years of treatment with TNF-α inhibitor etanercept, the patient was referred for a full neurological assessment after he reported balance disturbances, postural instability, muscle weakness, and other neurological symptoms that indicated the presence of a neurological disorder. After a thorough investigation, the patient was diagnosed with ALS. This case report aims to contribute to the limited literature by providing a detailed case study regarding the crosstalk between AS and ALS while also exploring the potential underlying mechanisms and the possible link between TNF-α inhibitors therapy and ALS.

Indexed as

Amyotrophic Lateral SclerosisSpondylitis, AnkylosingEtanerceptHumansMaleMiddle AgedSyndromeTumor Necrosis Factor-alphaEtanerceptTumor Necrosis Factor-alphaamyotrophic lateral sclerosisankylosing spondylitisoverlap syndromeTNF-α inhibitors

Identifiers

PMID39459490
PMCPMC11509627

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.