Evidence map›Paper›PMID 39459267›Full record

ArticleMolecules (Basel, Switzerland)2024

Synthesis, Urease Inhibition, Molecular Docking, and Optical Analysis of a Symmetrical Schiff Base and Its Selected Metal Complexes.

Samuel Bonne, Muhammad Saleem, Muhammad Hanif, Joseph Najjar, Salahuddin Khan, Muhammad Zeeshan, Tehreem Tahir, Anser Ali, Changrui Lu, Ting Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel BonneCollege of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China.ORCID 0009-0005-5373-4176
Muhammad SaleemDepartment of Chemistry, Thal University Bhakkar, Bhakkar 30000, Pakistan.ORCID 0000-0002-6441-5112
Muhammad HanifDepartment of Chemistry, GC University Faisalabad, Sub Campus, Layyah 31200, Pakistan.
Joseph NajjarFaculty of Medicine, McGill University, Montréal, QC H3A 0G4, Canada.
Salahuddin KhanCollege of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia.ORCID 0000-0002-6082-3418
Muhammad ZeeshanDepartment of Chemistry, GC University Faisalabad, Sub Campus, Layyah 31200, Pakistan.
Tehreem TahirDepartment of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, Pakistan.ORCID 0000-0002-1382-1946
Anser AliDepartment of Biological Sciences, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan.
Changrui LuCollege of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China.
Ting ChenCollege of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China.

Funding

Foundation of Shanghai Science and Technology Committee (No. 19410711000), China No. 19410711000
6 · The paper itself

Abstract

Designing and developing small organic molecules for use as urease inhibitors is challenging due to the need for ecosystem sustainability and the requirement to prevent health risks related to the human stomach and urinary tract. Moreover, imaging analysis is widely utilized for tracking infections in intracellular and in vivo systems, which requires drug molecules with emissive potential, specifically in the low-energy region. This study comprises the synthesis of a Schiff base ligand and its selected transition metals to evaluate their UV/fluorescence properties, inhibitory activity against urease, and molecular docking. Screening of the symmetrical cage-like ligand and its metal complexes with various eco-friendly transition metals revealed significant urease inhibition potential. The IC

Indexed as

Coordination ComplexesEnzyme InhibitorsMolecular Docking SimulationSchiff BasesUreaseHumansLigandsCoordination ComplexesEnzyme InhibitorsLigandsSchiff BasesUreaseenzyme kineticsmolecular dockingoptical analysisSchiff baseurease inhibition

Identifiers

PMID39459267
PMCPMC11510561

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.