Evidence map›Paper›PMID 39459039›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Hydrogel Containing Propolis: Physical Characterization and Evaluation of Biological Activities for Potential Use in the Treatment of Skin Lesions.

Lindalva Maria de Meneses Costa Ferreira, Naila Ferreira da Cruz, Desireé Gyles Lynch, Patrícia Fagundes da Costa, Claudio Guedes Salgado, José Otávio Carréra Silva-Júnior, Alessandra Rossi, Roseane Maria Ribeiro-Costa

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lindalva Maria de Meneses Costa FerreiraInstitute of Health Sciences, Federal University of Pará, Belem 66075-110, Brazil.ORCID 0000-0003-1966-6593
Naila Ferreira da CruzInstitute of Biological Sciences, Federal University of Pará, Belem 66075-110, Brazil.
Desireé Gyles LynchSchool of Pharmacy, College of Health Sciences, University of Technology, Jamaica, 237 Old Hope Road, Kinston 6, Jamaica.
Patrícia Fagundes da CostaInstitute of Biological Sciences, Federal University of Pará, Belem 66075-110, Brazil.
Claudio Guedes SalgadoInstitute of Biological Sciences, Federal University of Pará, Belem 66075-110, Brazil.ORCID 0000-0003-3961-7764
José Otávio Carréra Silva-JúniorCosmetic R&D Laboratory, Department Pharmaceutical, Faculty of Pharmaceutical Sciences, Federal University of Pará, Belem 66075-110, Brazil.ORCID 0000-0003-1691-1039
Alessandra RossiDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.ORCID 0000-0002-1480-753X
Roseane Maria Ribeiro-CostaInstitute of Health Sciences, Federal University of Pará, Belem 66075-110, Brazil.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

backgroundSkin injury affects the integrity of the skin structure and induces the wound healing process, which is defined by a well-coordinated series of cellular and molecular reactions that aim to recover or replace the injured tissue. Hydrogels are a group of promising biomaterials that are able to incorporate active ingredients for use as dressings. This study aimed to synthesize hydrogels with and without propolis extract and evaluate their physical characteristics and biological activities in vitro for potential use as active dressings in the treatment of skin lesions.

methodsThe antifungal [

resultsThe hydrogels showed good water absorption capacity, high solubility, and high gel fraction, as well as good porosity, water retention, and vapor transmission rates. They revealed a totally amorphous structure. The extract and the hydrogels containing the propolis extract (1.0% and 2.5%) did not inhibit fungal growth. However, they showed antibacterial activity against strains of

conclusionsTherefore, the hydrogels containing propolis extract can be a promising alternative with antibacterial and antioxidant action for use as dressings for the treatment of skin lesions.

Indexed as

antimicrobialantioxidantbiomaterialchronic woundsnatural product

Identifiers

PMID39459039
PMCPMC11510207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.