Evidence map›Paper›PMID 39459032›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats.

Alexandre Coelho Serquiz, Joana de Angelis da Costa Barros Gomes, Naisandra Bezerra da Silva Farias, Denise Mafra, Pietra Maria Pereira de Lima, Daniella de Oliveira Coutinho, Fernanda Priscila Barbosa Ribeiro, Hugo Alexandre de Oliveira Rocha, José Luiz de Brito Alves

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandre Coelho SerquizDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PS, Brazil.ORCID 0000-0002-1345-9705
Joana de Angelis da Costa Barros GomesLaboratory of Biotechnology of Natural Polymers (BIOPOL), Graduate Program of Biochemistry and Molecular Biology, Bioscience Center, Federal University of Rio Grande do Norte-UFRN, Natal 59078-970, RN, Brazil.
Naisandra Bezerra da Silva FariasLaboratory of Biotechnology of Natural Polymers (BIOPOL), Graduate Program of Biochemistry and Molecular Biology, Bioscience Center, Federal University of Rio Grande do Norte-UFRN, Natal 59078-970, RN, Brazil.
Denise MafraGraduate Program in Biological Sciences-Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-6752-6056
Pietra Maria Pereira de LimaDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PS, Brazil.
Daniella de Oliveira CoutinhoDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PS, Brazil.
Fernanda Priscila Barbosa RibeiroDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PS, Brazil.
Hugo Alexandre de Oliveira RochaLaboratory of Biotechnology of Natural Polymers (BIOPOL), Graduate Program of Biochemistry and Molecular Biology, Bioscience Center, Federal University of Rio Grande do Norte-UFRN, Natal 59078-970, RN, Brazil.
José Luiz de Brito AlvesDepartment of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-900, PS, Brazil.ORCID 0000-0003-4696-3809

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCadmium (Cd), a highly toxic heavy metal from agricultural activities, and its exposure can lead to impaired renal function by increasing reactive oxygen species. The atemoya fruit is known for its high phenolic and antioxidant compounds. This study aimed to evaluate the effects of atemoya extracts on renal function, oxidative stress parameters, and inflammatory biomarkers in a cadmium-induced nephrotoxicity model.

methodsThree aqueous extracts were prepared from different parts of the atemoya fruit: seeds, peel, and pulp. Twenty-five male

resultsThe cadmium-treated groups showed decreased creatinine clearance, SOD, CAT, and GPx activities (

conclusionsThis study supports the use of atemoya as a promising candidate for mitigating nephrotoxicity and highlights the importance of its antioxidant and anti-inflammatory properties in renal health.

Indexed as

atemoya fruitcadmiuminflammationnephrotoxicityoxidative stress

Identifiers

PMID39459032
PMCPMC11510283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.