ArticlePharmaceuticals (Basel, Switzerland)2024
Association between Scabies Treatment and Parkinson's Disease: A Nationwide, Population-Based Study.
Kao-Sung Tsai, Ming-Kuei Lu, Chao-Hong Liu, Fuu-Jen Tsai, Wen-Chi Chen, Huey-Yi Chen, Heng-Jun Lin, Cheng-Li Lin, Jen-Chih Lee, Kee-Ming Man and 2 more
Abstract read
In one paragraphArticle in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Kao-Sung TsaiSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-4410-4181 Ming-Kuei LuSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-2768-4399 Chao-Hong LiuDepartment of Electronics Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 824, Taiwan.ORCID 0000-0003-0887-8558 Fuu-Jen TsaiSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-1373-245X Wen-Chi ChenSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-6333-1638 Huey-Yi ChenSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-2808-8505 Heng-Jun LinSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0009-0003-1187-5494 Cheng-Li LinSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0001-9926-3668 Jen-Chih LeeDepartments of Pulmonary and Critical Care Medicine, Anesthesiology, Medical Research, Division of Family Medicine, Physical Examination Center, China Medical University Hsinchu Hospital, Hsinchu 302, Taiwan.
Kee-Ming ManDepartments of Pulmonary and Critical Care Medicine, Anesthesiology, Medical Research, Division of Family Medicine, Physical Examination Center, China Medical University Hsinchu Hospital, Hsinchu 302, Taiwan.ORCID 0000-0001-6618-6985 Chien-Yi HoSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.
Yung-Hsiang ChenSchool of Chinese Medicine, Graduate Institute of Integrated Medicine, College of Chinese Medicine, Ph.D. Program for Translational Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-8756-5113 Funding
China Medical University DMR-111-105; DMR-112-087; DMR-113-009; DMR-113-156; CMU112-S-04; CMUHCH-CMU-113-002Taiwan Ministry of Health and Welfare Clinical Trial Center MOHW113-TDU-B-212-114009
6 · The paper itselfAbstract
backgroundScabies is typically treated with scabicides like lindane, which poses a risk for acute neural toxicity. Lindane's prolonged use, particularly in agriculture, is linked to neurodegenerative diseases, including Parkinson's disease (PD), the second most common neurodegenerative disorder. This study aimed to evaluate whether scabies patients, particularly those treated with topical lindane, are at increased risk of developing PD.
methodsA nationwide population-based cohort study was conducted using data from Taiwan's National Health Research Institutes claims database from 2000 to 2018. The study included 27,173 patients with scabies, matched to a control group, with both groups followed for up to 18 years. The primary outcome was the incidence of newly diagnosed PD, and the hazard ratio (HR) for PD was calculated, focusing on those treated with topical lindane.
resultsAmong the 54,346 patients, 1639 (3.0%) were newly diagnosed with PD, with 993 (60.6%) from the scabies group and 646 (39.4%) from the control group. Scabies patients had an adjusted hazard ratio (aHR) of 1.46 (95% CI 1.32-1.63) for developing PD compared to controls. However, patients treated with topical lindane had a significantly lower aHR for PD at 0.15 (95% CI 0.12-0.19;
conclusionsScabies patients are at a 1.46-fold increased risk of developing PD, but those treated with lindane exhibit a significantly lower risk, suggesting potential protective effects of lindane against PD.
Indexed as
lindaneNational Health Insurance Research DatabaseParkinson’s diseasescabies
Identifiers
PMID39458983
PMCPMC11510565
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390