Evidence map›Paper›PMID 39458914›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Ionic Liquid-Based Grapeseed Oil Emulsion for Enhanced Anti-Wrinkle Treatment.

Bo Yang, Xu Zhang, Liguo Zhang, Jinjin Wu, Wei Wang, Qiaomei Huang, Zhenyuan Wang, Jichuan Zhang, Tongjie Xu, Chengyu Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bo YangSauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, China.ORCID 0009-0007-2050-8679
Xu ZhangHarbin Fuerjia Technology Co., Ltd., Harbin 150000, China.
Liguo ZhangHarbin Fuerjia Technology Co., Ltd., Harbin 150000, China.
Jinjin WuShenzhen Shinehigh Innovation Technology, Co., Ltd., Shenzhen 518056, China.
Wei WangHarbin Fuerjia Technology Co., Ltd., Harbin 150000, China.
Qiaomei HuangShenzhen Shinehigh Innovation Technology, Co., Ltd., Shenzhen 518056, China.
Zhenyuan WangShenzhen Shinehigh Innovation Technology, Co., Ltd., Shenzhen 518056, China.
Jichuan ZhangSauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, China.
Tongjie XuHarbin Fuerjia Technology Co., Ltd., Harbin 150000, China.
Chengyu WuCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.ORCID 0000-0003-1547-3516
Jiaheng ZhangSauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, China.ORCID 0000-0002-2377-9796

Funding

Department of Science and Technology of Guangdong Province 2020A1515110879Shenzhen Science and Technology Innovation Committee ZDSYS20190902093220279， KQTD20170809110344233, GXWD2020123-015542700320200821181245001, GXWD2020123015542700320200821181809001, and ZX20200151the National Natural Science Foundation of China 21905069 and U21A20307
6 · The paper itself

Abstract

objectivesTo address the poor efficacy and percutaneous penetration of grape seed oil, ionic liquids and nanotechnology were combined to prepare a grape seed oil emulsion.

methodsA novel Menthol-CoQ10 ionic liquid and ionic liquid based grapeseed oil emulsion were prepared and confirmed.

resultsThe average size of the grapeseed oil emulsion was 218 nm, and its zeta potential was -33.5 mV. The ionic liquid-based grape seed oil emulsion exhibited a transdermal penetration effect 4.63-fold higher than that of ordinary grape seed oil emulsion. Ionic liquid also displayed enhanced efficiency both in vitro and in vivo. It significantly inhibited the production of DPPH free radicals and tyrosinase, inhibited melanin and matrix metalloproteinase-1 (MMP-1) produced by cells, and promoted type I collagen expression in fibroblasts. After 28 days of continuous use, the grapeseed oil emulsion improved the water content of the stratum corneum and the rate of transepidermal water loss, enhanced the firmness and elasticity of the skin, and significantly improved the total number and length of under-eye lines, tail lines, nasolabial folds, and marionette lines on the face.

conclusionsMenthol-CoQ10 ionic liquid is a promising functional excipient for both transdermal delivery increase and efficient enhancement. Ionic liquid and nanotechnology for grape seed oil facial mask displayed significantly enhanced efficacy and permeability.

Indexed as

antiwrinkle treatmentenhanced efficacygrape seed oilionic liquidtransdermal penetration

Identifiers

PMID39458914
PMCPMC11510344

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.