Evidence map›Paper›PMID 39458540›Full record

ArticleNutrients2024

Association Between Gut Microbiome Composition and Physical Characteristics in Patients with Severe Motor and Intellectual Disabilities: Perspectives from Microbial Diversity.

Suzumi Kageyama, Rikako Inoue, Koji Hosomi, Jonguk Park, Hitomi Yumioka, Miki Doi, Miyuu Miyake, Yuka Nagashio, Yoshiko Shibuya, Nobue Oka and 5 more

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Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Suzumi KageyamaGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Rikako InoueDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.ORCID 0000-0002-1723-2444
Koji HosomiMicrobial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.
Jonguk ParkArtificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.ORCID 0000-0003-4872-385X
Hitomi YumiokaMicrobial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.
Miki DoiGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Miyuu MiyakeGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Yuka NagashioGraduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Yoshiko ShibuyaDepartment of Pediatrics, Asahigawasou Rehabilitation and Medical Center, Okayama 703-8207, Japan.
Nobue OkaDepartment of Pediatrics, Asahigawasou Rehabilitation and Medical Center, Okayama 703-8207, Japan.
Hirofumi AkazawaDepartment of Pediatrics, Asahigawasou Rehabilitation and Medical Center, Okayama 703-8207, Japan.
Susumu KanzakiDepartment of Pediatrics, Asahigawasou Rehabilitation and Medical Center, Okayama 703-8207, Japan.
Kenji MizuguchiArtificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.ORCID 0000-0003-3021-7078
Jun KunisawaMicrobial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.
Yasuyuki IrieDepartment of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.

Funding

Grant-in-Aid for the Japan Society for the Promotion of Science (JSPS) Fellows 23KJ1860Gushinkai Foundation 2021 General Grant N/AOkayama Prefectural University Creative Research Grant 2019C08, 2020J02, 2020D21, and 2021J02programs for Bridging the gap between R&d and the IDeal society (society 5.0) and Generating Economic and social value (BRiDGE) N/Athe Japan Agency for Medical Research and Development (AMED) JP2024ae0121035h0004 and 24ae0121039h0004the Ministry of Health, Labour and Welfare of Japan and Public/Private R&D Investment Strategic Expansion PrograM: PRISM 20AC5004
6 · The paper itself

Abstract

backgroundThe human gut environment undergoes substantial changes as a host ages. This investigation centered on the gut microbiome diversity among patients with severe motor and intellectual disabilities (SMID), examining the association between the gut microbiome composition and physical characteristics with varying levels of diversity.

methodsFourteen subjects were investigated, with physical and defecation status, blood biochemical test, gut microbiome profiling, and fecal metabolites used to divide the patients into a high-diversity group (HD, eight patients) and a low-diversity group (LD, six patients).

resultsFindings indicated that the microbiome of the LD group showed delayed maturation reminiscent of neonates and lactating infants. Analysis of the fecal bile acids (BAs) revealed a markedly diminished proportion of deoxycholic acid in the secondary BAs in the LD group, suggestive of inadequate conversion from primary to secondary BAs. Furthermore, the LD group presented with loose stools. The LD group exhibited a higher degree of physical severity, with all patients bedridden and fed via gastrostomy with only enteral formula received.

conclusionsThe composition of the gut microbiome and BAs in the LD group was found to differ from those of healthy individuals and the HD group, indicating a potentially immature gut environment for these individuals.

Indexed as

FecesGastrointestinal MicrobiomeIntellectual DisabilityAdolescentAdultBile Acids and SaltsChildFemaleHumansMaleMotor DisordersYoung AdultBile Acids and Saltsbile acidsfecal metabolitesgut microbiomematurationsevere motor and intellectual disabilities

Identifiers

PMID39458540
PMCPMC11510305

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.