Evidence map›Paper›PMID 39458532›Full record

ArticleNutrients2024

Sportomics Analyses of the Exercise-Induced Impact on Amino Acid Metabolism and Acute-Phase Protein Kinetics in Female Olympic Athletes.

Renan Muniz-Santos, Adriana Bassini, Jefferson Falcão, Eduardo Prado, LeRoy Martin, Vinod Chandran, Igor Jurisica, L C Cameron

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PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renan Muniz-SantosLorraine Protein Biochemistry Group, Graduate Program in Neurology, Gaffrée e Guinle University Hospital, Rio de Janeiro 20270-004, Brazil.
Adriana BassiniLaboratory of Protein Biochemistry, The Federal University of the State of Rio de Janeiro, Rio de Janeiro 22290-250, Brazil.
Jefferson FalcãoLaboratory for Research in Physical Exercise and Metabolism, Federal University of Alagoas, Maceió 57072-970, Brazil.
Eduardo PradoLorraine Protein Biochemistry Group, Graduate Program in Neurology, Gaffrée e Guinle University Hospital, Rio de Janeiro 20270-004, Brazil.
LeRoy MartinWaters Technologies, Milford, MA 01757, USA.
Vinod ChandranArthritis Program, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada.
Igor JurisicaOsteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada.
L C CameronLorraine Protein Biochemistry Group, Graduate Program in Neurology, Gaffrée e Guinle University Hospital, Rio de Janeiro 20270-004, Brazil.

Funding

Canada Foundation for Innovation CFI #225404, #30865Coordenação de Aperfeicoamento de Pessoal de Nível Superior NAFinanciadora de Estudos e Projetos NAFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro NAIan Lawson van Toch Fund NAIBM NAMerck Sigma Aldrich NANational Council for Scientific and Technological Development NANatural Sciences Research Council NSERC #203475Ontario Research Fund RDI #34876, RE010-020Universidade Federal do Estado do Rio de Janeiro NAUniversity of Toronto NAWaters Corporation NA
6 · The paper itself

Abstract

backgroundExercise can be used as a model to understand immunometabolism. Biological data on elite athletes are limited, especially for female athletes, including relevant data on acute-phase proteins and amino acid metabolism.

methodsWe analyzed acute-phase proteins and amino acids collected at South American, Pan-American, and Olympic Games for 16 Olympic sports. We compared female and male elite athletes (447 vs. 990 samples) across four states (fasting, pre-exercise, post-exercise, and resting) to understand sex-specific immunometabolic responses in elite athletes.

resultsConsidering all states and sports, we found that elite female athletes exhibited higher concentrations of C-reactive protein, lipopolysaccharide-binding protein, myeloperoxidase, haptoglobin, and IGF1, with ratios ranging from 1.2 to 2.0 (

conclusionWe established sex dimorphism in elite athletes' metabolic and inflammatory responses during training and competition. Our data suggest that female athletes present a lower amino acid response towards central fatigue development than male athletes. Understanding these differences can lead to insights into sex-related immuno-metabolic responses in sports or other inflammatory conditions.

Indexed as

Acute-Phase ProteinsAmino AcidsAthletesExerciseAdultC-Reactive ProteinFemaleHumansKineticsMaleSex CharacteristicsSex FactorsSportsYoung AdultAcute-Phase ProteinsAmino AcidsC-Reactive Proteinacute-phase proteinamino acid metabolismdried blood spotelite female athleteexercise immunologymass spectrometryOlympic Gamessportomics

Identifiers

PMID39458532
PMCPMC11510449

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.