Evidence map›Paper›PMID 39458471›Full record

Trial reportNutrients2024

Effect of Time-Restricted Eating on Circulating Levels of IGF1 and Its Binding Proteins in Obesity: An Exploratory Analysis of a Randomized Controlled Trial.

Rand Talal Akasheh, Aparna Ankireddy, Kelsey Gabel, Mark Ezpeleta, Shuhao Lin, Chandra Mohan Tamatam, Sekhar P Reddy, Bonnie Spring, Ting-Yuan David Cheng, Luigi Fontana and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rand Talal AkashehDepartment of Nutrition and Dietetics, American University of Madaba, Madaba P.O. Box 2882, Jordan.ORCID 0000-0002-0018-0342
Aparna AnkireddyDepartment of Pediatrics, University of Illinois Chicago, Chicago, IL 60607, USA.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0003-4613-8892
Mark EzpeletaDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-0746-2414
Shuhao LinDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-7982-746X
Chandra Mohan TamatamDepartment of Pediatrics, University of Illinois Chicago, Chicago, IL 60607, USA.
Sekhar P ReddyDepartment of Pediatrics, University of Illinois Chicago, Chicago, IL 60607, USA.
Bonnie SpringDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-0692-9868
Ting-Yuan David ChengDivision of Cancer Prevention and Control, Department of Internal Medicine, The Ohio State University, Columbus, OH 43214, USA.ORCID 0000-0002-4105-828X
Luigi FontanaCharles Perkins Centre RPA Clinic, Sydney Medical School, University of Sydney, Sydney 2009, Australia.
Seema Ahsan KhanDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-6307-2023
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.
Sofia CienfuegosDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-2225-527X
Faiza KalamDivision of Cancer Prevention and Control, Department of Internal Medicine, The Ohio State University, Columbus, OH 43214, USA.

Funding

Cancer Prevention, Control, and Survivorship Research Training ProgramT32CA193193 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Brian L Hitsman, BETINA YANEZ · 2015 to 2026
$3.8M
NIH HHS T32CA193193
6 · The paper itself

Abstract

Obesity is associated with alterations in circulating IGF1, IGF1-binding proteins (IGFBPs), insulin, inflammatory markers, and hormones implicated in cardiovascular disease, diabetes, cancer, and aging. However, the effects of 4 and 6 h time-restricted eating (TRE) on circulating IGF1 and IGFBPs is uncertain.

objectiveThis study aimed to investigate the effects of TRE on plasma IGF1, IGFBP1, IGFBP2, and IGFBP3, and whether these effects were mediated by weight loss or body composition changes. Insulin sensitivity, glucose control, adipokines, and inflammatory markers were also examined.

designAn exploratory analysis of an 8-week randomized controlled trial implementing a daily TRE intervention was carried out. PARTICIPANTS/

settingThis study was conducted at the University of Illinois at Chicago in 2019. Participants with obesity were randomized to 4 or 6 h TRE (n = 35) or a control (n = 14) group. Plasma biomarkers were measured by ELISA at baseline and week 8. In a sub-analysis, participants were stratified into higher- (>3.5%) and lower- (≤3.5%) weight-loss groups.

interventionParticipants fasted daily from 7 p.m. to 3 p.m. in the 4 h TRE group (20 h) and from 7 p.m. to 1 p.m. in the 6 h TRE group (18 h), followed by ad libitum eating for the remainder of the day. Controls received no dietary recommendations.

main outcome measuresIGF1, IGFBPs, hsCRP, and adipokines were the main outcome measures of this analysis. STATISTICAL ANALYSIS: Repeated measures ANOVA and mediation analysis were conducted.

resultsBody weight significantly decreased with TRE (-3.6 ± 0.3%), contrasting with controls (+0.2 ± 0.5%,

conclusionsEight-week daily 4 to 6 h TRE did not affect IGF1, IGFBP1, or IGFBP3 levels but improved insulin, HOMA-IR, and 8-isoprostane. IGFBP2 increased and leptin decreased when weight loss exceeded 3.5% of baseline.

Indexed as

BiomarkersInsulin-Like Growth Factor IObesityAdipokinesAdultBody CompositionFastingFemaleHumansInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsInsulin ResistanceMaleMiddle AgedAdipokinesBiomarkersIGF1 protein, humanInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor Igrowth hormonesIGF1IGFBPinsulinintermittent fastingobesity

Identifiers

PMID39458471
PMCPMC11510611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.