Evidence map›Paper›PMID 39458305›Full record

ArticleMicroorganisms2024

Ionizing Radiation Dose Differentially Affects the Host-Microbe Relationship over Time.

Nabarun Chakraborty, Allison Hoke, Ross Campbell, Gregory Holmes-Hampton, Vidya P Kumar, Candace Moyler, Aarti Gautam, Rasha Hammamieh, Sanchita P Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nabarun ChakrabortyMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Allison HokeMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-4939-7515
Ross CampbellMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Gregory Holmes-HamptonArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD 20889, USA.
Vidya P KumarArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD 20889, USA.ORCID 0000-0002-6321-7640
Candace MoylerMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Aarti GautamMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Rasha HammamiehMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Sanchita P GhoshArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD 20889, USA.ORCID 0000-0002-0261-460X

Funding

JPC-7 project and the AFRRI Intramural funding DM178020 and RAB23338
6 · The paper itself

Abstract

Microorganisms that colonize in or on a host play significant roles in regulating the host's immunological fitness and bioenergy production, thus controlling the host's stress responses. Radiation elicits a pro-inflammatory and bioenergy-expensive state, which could influence the gut microbial compositions and, therefore, the host-microbe bidirectional relationship. To test this hypothesis, young adult mice were exposed to total body irradiation (TBI) at doses of 9.5 Gy and 11 Gy, respectively. The irradiated mice were euthanized on days 1, 3, and 9 post TBI, and their descending colon contents (DCCs) were collected. The 16S ribosomal RNAs from the DCCs were screened to find the differentially enriched bacterial taxa due to TBI. Subsequently, these data were analyzed to identify the metagenome-specific biofunctions. The bacterial community of the DCCs showed increased levels of diversity as time progressed following TBI. The abundance profile was the most divergent at day 9 post 11 Gy TBI. For instance, an anti-inflammatory and energy-harvesting bacterium, namely,

Indexed as

16S rRNA gene sequencingdescending colon contentsfecal metabolitefecal microbiomefunctional metagenomehost–microbiome associationtotal body irradiation

Identifiers

PMID39458305
PMCPMC11509422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.