ArticleBiomedicines2024
Central Neck Dissection in Papillary Thyroid Carcinoma: Benefits and Doubts in the Era of Thyroid Lobectomy.
Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Single-cell transcriptomic analysis reveals tumor-immune determinants of lymph node colonization and progression in thyroid cancer.Science advances · 2026Article
- A nomogram-based risk stratification strategy to optimize central lymph node dissection in cN1a papillary thyroid cancer with Hashimoto's thyroiditis.Gland surgery · 2026Article
- The association of Hashimoto's thyroiditis with central lymph node metastasis in papillary thyroid cancer: a retrospective cross-sectional study.Gland surgery · 2026Article
- Clinicopathological predictors of central lymph node metastasis in clinically node-negative papillary thyroid carcinoma: a retrospective cohort analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Case Report: The clear cell variant of papillary thyroid carcinoma: a clinicopathologic study of four cases with emphasis onFrontiers in oncology · 2026Article
- Article
- Mitoxantrone hydrochloride injection guided sentinel lymph node biopsy in cN0 BRAF V600E-mutated papillary thyroid carcinoma: a feasibility study.Frontiers in endocrinology · 2025Article
- AI-based multimodal prediction of lymph node metastasis and capsular invasion in cT1N0M0 papillary thyroid carcinoma.Frontiers in endocrinology · 2025Article
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Authors and funding
14 authors.
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Abstract
introductionSurgery is still the main line of treatment for papillary thyroid cancer (PTC) with a current trend for de-intensified treatment based on an excellent prognosis. The role of a routine prophylactic central neck dissection (PCND) is still debated as its impact on oncologic outcomes has never been cleared by a randomized clinical trial. In this study, we aimed to report our long-standing experience in PCND and its potential contemporary role in the treatment of PTC.
methodsA retrospective institutional review was performed on all patients who underwent operation for PTC including PCND between 1998 and 2021. The primary outcomes were the rate of central lymph node metastases (CLNMs), cancer recurrence and incidence of complications. Survivals were analyzed using the Kaplan-Meier estimator and Cox proportional hazard models.
resultsA total of 657 patients were included in this study with a median follow-up of 78 months (48-114 months). Two hundred and one patients presented occult CLNMs (30.6%). The presence of a pathological node represented the unique reason for a completion thyroidectomy and I
conclusionsPCND allows for a high disease-free survival and a proper selection of patients needing adjuvant treatment, in particular, those treated with a unilateral procedure. On the other hand, bilateral approach is burdened by a not-neglectable rate of permanent hypoparathyroidism.
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