Evidence map›Paper›PMID 39457057›Full record

ArticleInternational journal of molecular sciences2024

Design and Synthesis of Potential Multi-Target Antidepressants: Exploration of 1-(4-(7-Azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1

Martyna Z Wróbel, Andrzej Chodkowski, Agata Siwek, Grzegorz Satała, Andrzej J Bojarski, Maciej Dawidowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Decoding serotonin: the molecular symphony behind depression.Frontiers in cellular neuroscience · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martyna Z WróbelDepartment of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.ORCID 0000-0001-6201-4756
Andrzej ChodkowskiDepartment of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.
Agata SiwekDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Grzegorz SatałaDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.
Andrzej J BojarskiDepartment of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.ORCID 0000-0003-1417-6333
Maciej DawidowskiDepartment of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.ORCID 0000-0002-7262-5718

Funding

National Science Center 2013/09/B/NZ7/00748
6 · The paper itself

Abstract

We describe the design, synthesis and structure-activity relationship of a novel series of 1-(4-(7-azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1

Indexed as

Antidepressive AgentsDrug DesignIndolesSerotonin Plasma Membrane Transport ProteinsAnimalsDopamine Plasma Membrane Transport ProteinsHumansPyrrolidinesReceptors, Dopamine D2Receptor, Serotonin, 5-HT1AStructure-Activity RelationshipAntidepressive AgentsDopamine Plasma Membrane Transport ProteinsIndolesPyrrolidinesReceptors, Dopamine D2Receptor, Serotonin, 5-HT1ASerotonin Plasma Membrane Transport Proteins5-HT1A receptor ligandsantidepressant drugsdrug design and discoverymulti-target directed ligandsserotonin reuptake inhibitorstriple reuptake inhibitors

Identifiers

PMID39457057
PMCPMC11508649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.