Evidence map›Paper›PMID 39457023›Full record

ArticleInternational journal of molecular sciences2024

Evaluation of Blood-Brain Barrier Disruption Using Low- and High-Molecular-Weight Complexes in a Single Brain Sample in a Rat Traumatic Brain Injury Model: Comparison to an Established Magnetic Resonance Imaging Technique.

Vladislav Zvenigorodsky, Benjamin F Gruenbaum, Ilan Shelef, Anat Horev, Abed N Azab, Anna Oleshko, Mammduch Abu-Rabia, Shahar Negev, Alexander Zlotnik, Israel Melamed and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vladislav ZvenigorodskyDepartment of Radiology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
Benjamin F GruenbaumDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3120-5709
Ilan ShelefDepartment of Radiology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.ORCID 0000-0002-8398-6455
Anat HorevDepartment of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
Abed N AzabDepartment of Nursing, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
Anna OleshkoDepartment of Biology and Methods of Teaching Biology, A. S. Makarenko Sumy State Pedagogical University, 40002 Sumy, Ukraine.
Mammduch Abu-RabiaDepartment of Anesthesiology and Critical Care, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
Shahar NegevDepartment of Anesthesiology and Critical Care, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
Alexander ZlotnikDepartment of Anesthesiology and Critical Care, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
Israel MelamedDepartment of Neurosurgery, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
Matthew BoykoDepartment of Anesthesiology and Critical Care, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.ORCID 0000-0003-3116-1643

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI), a major cause of death and disability among young people, leads to significant public health and economic challenges. Despite its frequency, treatment options remain largely unsuitable. However, examination of the blood-brain barrier (BBB) can assist with understanding the mechanisms and dynamics of brain dysfunction, which affects TBI sufferers secondarily to the injury. Here, we present a rat model of TBI focused on two standard BBB assessment markers, high- and low-molecular-weight complexes, in order to understand BBB disruption. In addition, we tested a new technique to evaluate BBB disruption on a single brain set, comparing the new technique with neuroimaging. A total of 100 Sprague-Dawley rats were separated into the following five groups: naive rats (

Indexed as

Blood-Brain BarrierBrain Injuries, TraumaticDisease Models, AnimalMagnetic Resonance ImagingRats, Sprague-DawleyAnimalsBrainMaleMolecular WeightRatsanimal modelblood–brain barrierhigh-molecular-weight complexlow-molecular-weight complexmagnetic resonance imagingtraumatic brain injury

Identifiers

PMID39457023
PMCPMC11508800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.