Evidence map›Paper›PMID 39456966›Full record

ArticleInternational journal of molecular sciences2024

Application of hs-CRP in Assessment of Tissue Inflammation Following Implantation of Biodegradable Polymer in Experiment.

Igor A Eisenach, Galina A Lapii, Alexandra K Uzyumova, Elena L Lushnikova, Victor S Ovchinnikov, Anastasia O Solovieva, Vasiliy A Naprimerov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Clinical progress and prospects of biodegradable intestinal stents.American journal of translational research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Igor A EisenachInstitute of Molecular Pathology and Pathomorphology, Federal Research Center for Fundamental and Translational Medicine, 2 Timakova St., Novosibirsk 630117, Russia.ORCID 0000-0002-0895-2626
Galina A LapiiInstitute of Molecular Pathology and Pathomorphology, Federal Research Center for Fundamental and Translational Medicine, 2 Timakova St., Novosibirsk 630117, Russia.
Alexandra K UzyumovaInstitute of Molecular Pathology and Pathomorphology, Federal Research Center for Fundamental and Translational Medicine, 2 Timakova St., Novosibirsk 630117, Russia.
Elena L LushnikovaInstitute of Molecular Pathology and Pathomorphology, Federal Research Center for Fundamental and Translational Medicine, 2 Timakova St., Novosibirsk 630117, Russia.
Victor S OvchinnikovResearch Institute of Clinical and Experimental Lymphology, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 6 Arbuzova, Novosibirsk 630060, Russia.ORCID 0000-0002-3975-0939
Anastasia O SolovievaResearch Institute of Clinical and Experimental Lymphology, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 6 Arbuzova, Novosibirsk 630060, Russia.ORCID 0000-0002-7740-8456
Vasiliy A NaprimerovThe Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Prospekt Lavrentyeva, Novosibirsk 630090, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implants made of biodegradable polymers are replaced by regenerating tissues through inflammation. The changes occurring in tissues and the organism are of practical interest for studying the biocompatibility of the material and searching for systemic markers in the blood that reflect inflammation in peri-implantation tissues. The highly sensitive C-reactive protein (hs-CRP) measurements in blood and morphometric studies of tissue surrounding the implant were carried out in the experiment within three months of implantation of a biopolymer consisting of polycaprolactone (PCL) and polytrimethylene carbonate (PTMC). During the first month, tissue inflammation decreased, and the blood level of hs-CRP did not increase. The polymer biotransformation began in the tissues after a month of implantation and was accompanied by inflammation moving deeper into the matrix. Proliferation of inflammatory cells in tissues was reflected in an increase in the hs-CRP level three months after polymer installation. The result achieved confirmed the polymer's bioinertness. The level of hs-CRP in the blood of the animals correlated with the level of inflammation in peri-implantation tissues, reflecting the activity of inflammation in the process of polymer biotransformation. This inflammation protein can be recommended for assessing tissue processes following implantation of biopolymers and their biocompatibility.

Indexed as

Absorbable ImplantsBiocompatible MaterialsC-Reactive ProteinInflammationPolyestersPolymersAnimalsBiomarkersDioxanesMaleMaterials TestingRatsBiocompatible MaterialsBiomarkersC-Reactive ProteinDioxanespolycaprolactonePolyestersPolymerspolytrimethylene carbonatebiodegradable polymerbioinertnesshighly sensitive C-reactive protein (hs-CRP)implantinflammationtissue reaction

Identifiers

PMID39456966
PMCPMC11508534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.