ArticleInternational journal of molecular sciences2024
Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids Against Cholinesterases: In Silico, In Vitro, and In Vivo Studies.
Carlos M Gastalho, Ana M Sena, Óscar López, José G Fernández-Bolaños, Alfonso T García-Sosa, Florbela Pereira, Célia M Antunes, Ana R Costa, Anthony J Burke, Elisabete P Carreiro
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In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Carlos M GastalhoLAQV-REQUIMTE, Institute for Research and Advanced Training (IIFA), University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.ORCID 0000-0002-4077-9755 Ana M SenaDepartment of Chemistry and Biochemistry, School of Sciences and Technologies, University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.ORCID 0000-0001-5397-8684 Óscar LópezDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain.
José G Fernández-BolañosDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain.
Alfonso T García-SosaInstitute of Chemistry, University of Tartu, Ravila 14 A, 50411 Tartu, Estonia.ORCID 0000-0003-0542-4446 Florbela PereiraLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0003-4392-4644 Célia M AntunesInstitute of Earth Sciences, Institute of Research and Advanced Training, University of Évora, 7000-671 Évora, Portugal.ORCID 0000-0001-8906-1085 Ana R CostaInstitute of Earth Sciences, Institute of Research and Advanced Training, University of Évora, 7000-671 Évora, Portugal.ORCID 0000-0003-3854-9130 Anthony J BurkeLAQV-REQUIMTE, Institute for Research and Advanced Training (IIFA), University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.
Elisabete P CarreiroLAQV-REQUIMTE, Institute for Research and Advanced Training (IIFA), University of Évora, Rua Romão Ramalho, 59, 7000-671 Évora, Portugal.ORCID 0000-0001-8117-7737 Funding
Estonian Research Council grant PRG1509Fundação para a Ciência e a tecnologia UIDB/00313/2020 | UIDP/00313/2020Fundação para a Ciência e a Tecnologia FCT/ MCTES; UIDB/50006/2020|UIDP/50006/2020MCIN/AEI/10.13039/501100011033 PID2020-116460RB-I00
6 · The paper itselfAbstract
Combining the pharmacological properties of the 1,2,3-triazole and dihydropyrimidinone classes of compounds, two small families of mono- and di(1,2,3-triazole)-dihydropyrimidinone hybrids, A and B, were previously synthesized. The main objective of this work was to investigate the potential anti-Alzheimer effects of these hybrids. The inhibitory activities of cholinesterases (AChE and BuChE), antioxidant activity, and the inhibitory mechanism through in silico (molecular docking) and in solution (STD-NMR) experiments were evaluated. The 1,2,3-triazole-dihydropyrimidinone hybrids (A and B) showed moderate in vitro inhibitory activity on eqBuChE (IC
Indexed as
ButyrylcholinesteraseCholinesterase InhibitorsMolecular Docking SimulationPyrimidinonesTriazolesAcetylcholinesteraseAnimalsAntioxidantsComputer SimulationHumansAcetylcholinesteraseAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsPyrimidinonesTriazoles1,2,3-triazoleantioxidant activitycholinesterasesdihydropyrimidinonedockingSTD-NMR
Identifiers
PMID39456935
PMCPMC11508620
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