Evidence map›Paper›PMID 39456863›Full record

ArticleInternational journal of molecular sciences2024

Cytokines Measured in Nasal Lavage Compared to Induced Sputum in Patients with Mild Cystic Fibrosis.

Teresa Fuchs, Artemis Vasiliadis, Manuela Zlamy, Anja Siedl, Katharina Niedermayr, Dorothea Appelt, Verena Gasser, Johannes Eder, Helmut Ellemunter

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Teresa FuchsDepartment of Child and Adolescent Health, Paediatrics III, Cystic Fibrosis Centre Innsbruck, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-1002-1185
Artemis VasiliadisDepartment of Child and Adolescent Health, Paediatrics III, Cystic Fibrosis Centre Innsbruck, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Manuela ZlamyPraxis Dr. Zlamy, Kirchstrasse 10, 6091 Götzens, Austria.
Anja SiedlDepartment of Child and Adolescent Health, Pediatrics III, Tirol Kliniken, Cystic Fibrosis Centre Innsbruck, 6020 Innsbruck, Austria.
Katharina NiedermayrDepartment of Child and Adolescent Health, Pediatrics III, Tirol Kliniken, Cystic Fibrosis Centre Innsbruck, 6020 Innsbruck, Austria.
Dorothea AppeltDepartment of Child and Adolescent Health, Paediatrics III, Cystic Fibrosis Centre Innsbruck, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0009-0007-0030-5356
Verena GasserDepartment of Child and Adolescent Health, Pediatrics III, Tirol Kliniken, Cystic Fibrosis Centre Innsbruck, 6020 Innsbruck, Austria.
Johannes EderDepartment of Child and Adolescent Health, Pediatrics III, Tirol Kliniken, Cystic Fibrosis Centre Innsbruck, 6020 Innsbruck, Austria.
Helmut EllemunterDepartment of Child and Adolescent Health, Paediatrics III, Cystic Fibrosis Centre Innsbruck, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The measurement of cytokines in induced sputum and nasal lavage (NL) samples has been performed for years in people with cystic fibrosis (CF). The aim of this study was to directly compare sputum and NL samples and interpret results based on disease severity in patients who were categorized as having mild or severe lung disease. The categorization was based primarily on structural abnormalities detected on lung computed tomography and secondarily on lung function. The serum inflammatory markers neutrophil elastase (NE), IL-1β, 2, 6, 8, 10 and 17a were measured in each sputum and NL sample. Thirty-two sample pairs from 29 patients were included in this study (13 mild, 19 severe). In the patients classified as severe, many systemic inflammatory markers as well as sputum cytokines were significantly higher compared to those in the mild patients. However, all the markers measured in the NL were higher in the mild patients (

Indexed as

BiomarkersCystic FibrosisCytokinesSputumAdolescentAdultFemaleHumansLeukocyte ElastaseMaleNasal LavageNasal Lavage FluidSeverity of Illness IndexYoung AdultBiomarkersCytokinesLeukocyte Elastasecystic fibrosiscytokinesinduced sputuminflammationnasal lavageserum

Identifiers

PMID39456863
PMCPMC11507901

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.