Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models.

Jisheng Li, Bowen Zhang, Yunqiao Li, Chuanli Liu, Xuan Tang, Jiahui Zhao, Xuetao Pei, Yanhua Li

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jisheng LiBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0001-9109-5815

Bowen ZhangBeijing Institute of Radiation Medicine, Beijing 100850, China.

Yunqiao LiBeijing Institute of Radiation Medicine, Beijing 100850, China.

Chuanli LiuBeijing Institute of Radiation Medicine, Beijing 100850, China.

Xuan TangBeijing Institute of Radiation Medicine, Beijing 100850, China.

Jiahui ZhaoBeijing Institute of Radiation Medicine, Beijing 100850, China.

Xuetao PeiBeijing Institute of Radiation Medicine, Beijing 100850, China.

Yanhua LiBeijing Institute of Radiation Medicine, Beijing 100850, China.

Funding

National Natural Science Foundation of China 82200122

6 · The paper itself

Abstract

Serine and folate metabolism play critical roles in erythroid development in both embryonic and adult mice; however, the precise roles of these metabolic pathways in erythropoiesis and the pathophysiology of anemia remain inadequately characterized in the literature. To delineate the contributions of serine and folate metabolism to erythroid differentiation, we focused on serine hydroxymethyltransferase 2 (SHMT2), a key regulatory enzyme within these metabolic pathways. Using gene-editing techniques, we created fetal and adult mouse models with targeted deletion of

Indexed as

AnemiaDisease Models, AnimalErythropoiesisGlycine HydroxymethyltransferaseAnimalsCell DifferentiationErythroid CellsFolic AcidHematopoietic SystemHydroxymethyl and Formyl TransferasesMiceMice, Inbred C57BLMice, KnockoutFolic AcidGlycine HydroxymethyltransferaseHydroxymethyl and Formyl TransferasesShmt2 protein, mouseanemiabone marrowerythroid differentiationred blood cellserine hydroxymethyltransferase 2Vav1-Cre

Identifiers

PMID39456851

DOI10.3390/ijms252011072

PMCPMC11508403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.