Evidence map›Paper›PMID 39456838›Full record

ArticleInternational journal of molecular sciences2024

High Ki-67 Expression Predicting a Risk Factor for the Progression of Disease within 24 Months and Microenvironment in Follicular Lymphoma.

Hinako Narita, Kai Kuroiwa, Yukiko Kawaguchi, So Murai, Yosuke Sasaki, Mayumi Homma, Natsuki Kawamata, Hidenori Hayashi, Kazuki Nagao, Reiko Okamura and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Digital and Manual Assessment of Intrafollicular Ki-67,Diagnostics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Hinako NaritaDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Kai KuroiwaDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Yukiko KawaguchiDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.ORCID 0000-0001-5988-1031
So MuraiDepartment of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Yosuke SasakiDepartment of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.ORCID 0000-0003-0786-9780
Mayumi HommaDepartment of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Natsuki KawamataDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Hidenori HayashiDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Kazuki NagaoDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Reiko OkamuraDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Yuka UesugiDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.ORCID 0000-0001-9334-8126
Yohei SasakiDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Shotaro ShimadaDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Megumi WatanukiDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Nana AraiDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Kouji YanagisawaDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Eisuke ShiozawaDepartment of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.ORCID 0000-0003-4764-7496
Toshiko YamochiDepartment of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.
Norimichi HattoriDivision of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan.ORCID 0000-0002-9404-7074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most follicular lymphomas (FLs) demonstrate an indolent clinical course with favorable outcomes; however, a fraction of patients experiences progression of disease within 24 months (POD24) and has adverse outcomes. This study aimed to determine the predictive risk factors for POD24 in patients with FL, and the characteristics of the microenvironment in FL with POD24. By multivariate analysis, we revealed that increased Ki-67 expression was associated with POD24 events in patients with FL (hazard ratio [HR]: 6.29, 95% confidence interval [CI]: 1.96-20.22,

Indexed as

Disease ProgressionKi-67 AntigenLymphoma, FollicularTumor MicroenvironmentAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedPrognosisRisk FactorsBiomarkers, TumorKi-67 Antigenfollicular lymphomaKi-67macrophagePOD24tumor microenvironment

Identifiers

PMID39456838
PMCPMC11507466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.