Evidence map›Paper›PMID 39456832›Full record

ArticleInternational journal of molecular sciences2024

Immune Checkpoint Inhibitor Therapy and Associations with Clonal Hematopoiesis.

Abhay Singh, Nuria Mencia Trinchant, Rahul Mishra, Kirti Arora, Smit Mehta, Teodora Kuzmanovic, Maedeh Zokaei Nikoo, Inderpreet Singh, Amanda C Przespolewski, Mahesh Swaminathan and 10 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Abhay SinghLeukemia and Myeloid Disorders Program, Cleveland Clinic, Cleveland, OH 44106, USA.
Nuria Mencia TrinchantDivision of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Rahul MishraDepartment of Internal Medicine, Anne Arundel Medical Center, Annapolis, MD 21401, USA.ORCID 0000-0001-5631-1164
Kirti AroraDepartment of Medicine, Cleveland Clinic Akron General Hospital, Akron, OH 44307, USA.
Smit MehtaLeukemia and Myeloid Disorders Program, Cleveland Clinic, Cleveland, OH 44106, USA.ORCID 0009-0007-9440-0644
Teodora KuzmanovicLeukemia and Myeloid Disorders Program, Cleveland Clinic, Cleveland, OH 44106, USA.
Maedeh Zokaei NikooUniversity Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA.
Inderpreet SinghUpstate Community Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA.ORCID 0009-0000-8999-9532
Amanda C PrzespolewskiDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Mahesh SwaminathanDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Marc S ErnstoffDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.ORCID 0000-0002-8132-7069
Grace K DyDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Lunbiao YanDivision of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Eti SinhaDivision of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0003-4680-0321
Shruti SharmaUpstate Community Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Duane C HassaneDivision of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Elizabeth A GriffithsDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Eunice WangDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.ORCID 0000-0002-8644-0968
Monica L GuzmanDivision of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Swapna ThotaDepartment of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.ORCID 0000-0002-4216-1414

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
NCI NIH HHS P30 CA016056
6 · The paper itself

Abstract

Cancer cohorts are now known to be associated with increased rates of clonal hematopoiesis (CH). We sort to characterize the hematopoietic compartment of patients with melanoma and non-small cell lung cancer (NSCLC) given our recent population level analysis reporting evolving rates of secondary leukemias. The advent of immune checkpoint blockade (ICB) has dramatically changed our understanding of cancer biology and has altered the standards of care for patients. However, the impact of ICB on hematopoietic myeloid clonal expansion remains to be determined. We studied if exposure to ICB therapy affects hematopoietic clonal architecture and if their evolution contributed to altered hematopoiesis. Blood samples from patients with melanoma and NSCLC (

Indexed as

Carcinoma, Non-Small-Cell LungClonal HematopoiesisDioxygenasesDNA Methyltransferase 3AImmune Checkpoint InhibitorsMelanomaMutationAdultAgedDNA-Binding ProteinsFemaleHumansLung NeoplasmsMaleMiddle AgedProto-Oncogene ProteinsDioxygenasesDNA-Binding ProteinsDNA Methyltransferase 3ADNMT3A protein, humanImmune Checkpoint InhibitorsProto-Oncogene ProteinsTET2 protein, humanclonal hematopoiesis of indeterminate potentialDNMT3Aimmune checkpoint blockadeimmune checkpoint inhibitormelanomanon-small cell lung cancerTET2

Identifiers

PMID39456832
PMCPMC11508050

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.