Evidence map›Paper›PMID 39456827›Full record

ArticleInternational journal of molecular sciences2024

The Impact of Different Anesthetics on the Distribution and Cytotoxic Function of NK Cell Subpopulations: An In Vitro Study.

Tristan J Vulcano, Wayel H Abdulahad, Matijs van Meurs, Rianne M Jongman, Michel M R F Struys, Dirk J Bosch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tristan J VulcanoDepartment of Anaesthesiology, University Medical Centre Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0009-0000-1891-8213
Wayel H AbdulahadDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-3109-4487
Matijs van MeursDepartment of Pathology and Medical Biology, University Medical Centre Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The Netherlands.
Rianne M JongmanDepartment of Anaesthesiology, University Medical Centre Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-7521-9096
Michel M R F StruysDepartment of Anaesthesiology, University Medical Centre Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-0421-536X
Dirk J BoschDepartment of Anaesthesiology, University Medical Centre Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-8275-5321

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Only some subpopulations of natural killer (NK) cells have cytotoxic functionality, and the effects of anesthetics on these subpopulations are unknown. This study aimed to evaluate the in vitro effects of various anesthetics, both alone and in combination, on the distribution and cytotoxic function of NK cells and their subpopulations. Peripheral blood mononuclear cells (PBMCs) from eight healthy volunteers were treated for 4 h in vitro with dexmedetomidine, remifentanil, lidocaine, propofol, sevoflurane, and combinations in clinically relevant concentrations or left untreated. Flow cytometry was used to quantify the percentage of sampled NK cells and evaluate their distribution (CD56

Indexed as

Killer Cells, NaturalAdultAnestheticsCD56 AntigenCytotoxicity, ImmunologicDexmedetomidineFemaleFlow CytometryHumansLeukocytes, MononuclearLidocaineMalePropofolRemifentanilSevofluraneAnestheticsCD56 AntigenDexmedetomidineLidocainePropofolRemifentanilSevofluraneimmunologylidocainenatural killer cellspropofolsevofluranetotal intravenous anesthesiavolatile anesthetics

Identifiers

PMID39456827
PMCPMC11507532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.