Evidence map›Paper›PMID 39456740›Full record

ArticleInternational journal of molecular sciences2024

T-Cell Dynamics Predicts Prognosis of Patients with Hepatocellular Carcinoma Receiving Atezolizumab Plus Bevacizumab.

Hye Won Lee, Suebin Park, Hye Jung Park, Kyung Joo Cho, Do Young Kim, Byungjin Hwang, Jun Yong Park

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Ubiquitination in hepatocellular carcinoma immunity.Journal of translational medicine · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hye Won LeeDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0002-3552-3560
Suebin ParkDepartment of Clinical Drug Discovery & Development, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Hye Jung ParkDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Kyung Joo ChoDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Do Young KimDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0002-8327-3439
Byungjin HwangGraduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Jun Yong ParkDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0001-6324-2224

Funding

Handok Inc 2023-2123-001Mid-Career Researcher Program NRF-2018R1A2A1A05079172
6 · The paper itself

Abstract

Atezolizumab and bevacizumab show promise for treating hepatocellular carcinoma (HCC), but identifying responsive patients remains challenging, due to tumor heterogeneity. This study explores immune dynamics following this combination therapy. Between 2020 and 2023, 29 patients with advanced HCC who received atezolizumab plus bevacizumab at Severance Hospital, Seoul, were enrolled in this study. Peripheral blood mononuclear cells were analyzed using flow cytometry and statistical methods to assess immune alterations and identify biomarkers. Baseline characteristics showed a diverse HCC cohort with a mean age of 64 years and 82.8% male predominance. Absence of extrahepatic metastasis was associated with better overall survival. Immune responses revealed distinct CD4

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsBevacizumabCarcinoma, HepatocellularLiver NeoplasmsAgedCD8-Positive T-LymphocytesFemaleHumansMaleMiddle AgedPrognosisT-LymphocytesAntibodies, Monoclonal, HumanizedatezolizumabBevacizumabatezolizumabbevacizumabhepatocellular carcinomaimmune dynamicsprognostic markers

Identifiers

PMID39456740
PMCPMC11507274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.