Evidence map›Paper›PMID 39456736›Full record

ArticleInternational journal of molecular sciences2024

Trp53 Deletion Promotes Exacerbated Colitis, Facilitates Lgr5+ Cancer Stem Cell Expansion, and Fuels Tumorigenesis in AOM/DSS-Induced Colorectal Cancer.

Anderson F Cunha, João M Delou, Pedro S Barbosa, Julia S M Conceição, Karen C S Souza, Vera Chagas, Rossana C Soletti, Heitor S P de Souza, Helena L Borges

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anderson F CunhaInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-90, RJ, Brazil.
João M DelouInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-90, RJ, Brazil.ORCID 0000-0003-1141-5351
Pedro S BarbosaInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-90, RJ, Brazil.ORCID 0000-0003-2065-8451
Julia S M ConceiçãoInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-90, RJ, Brazil.ORCID 0009-0005-8967-4486
Karen C S SouzaDepartamento de Clínica Médica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil.
Vera ChagasDepartamento de Patologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil.
Rossana C SolettiDepartamento Interdisciplinar, Universidade Federal do Rio Grande do Sul, Tramandaí 95590-000, RS, Brazil.
Heitor S P de SouzaDepartamento de Clínica Médica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil.ORCID 0000-0002-3647-7324
Helena L BorgesInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-90, RJ, Brazil.ORCID 0000-0003-2866-4223

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 201.201/2022 273290National Council for Scientific and Technological Development Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro
6 · The paper itself

Abstract

Colorectal cancer CRC remains one of the leading causes of cancer-related deaths worldwide, with chronic intestinal inflammation identified as a major risk factor. Notably, the tumor suppressor

Indexed as

AzoxymethaneCarcinogenesisColitisColorectal NeoplasmsDextran SulfateMice, KnockoutNeoplastic Stem CellsReceptors, G-Protein-CoupledTumor Suppressor Protein p53AnimalsDisease Models, AnimalGene DeletionMiceMice, Inbred C57BLAzoxymethaneDextran SulfateLgr5 protein, mouseReceptors, G-Protein-CoupledTrp53 protein, mouseTumor Suppressor Protein p53colorectal cancerinflammatory bowel diseaseLgr5p53

Identifiers

PMID39456736
PMCPMC11507199

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.