Evidence map›Paper›PMID 39456505›Full record

ArticleAntioxidants (Basel, Switzerland)2024

AIBP Protects Müller Glial Cells Against Oxidative Stress-Induced Mitochondrial Dysfunction and Reduces Retinal Neuroinflammation.

Seunghwan Choi, Soo-Ho Choi, Tonking Bastola, Keun-Young Kim, Sungsik Park, Robert N Weinreb, Yury I Miller, Won-Kyu Ju

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Cellular responses of human Muller glia exposed to test dust pollution.Environmental pollution (Barking, Essex : 1987) · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seunghwan ChoiHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA.
Soo-Ho ChoiDepartment of Medicine, University of California San Diego, La Jolla, CA 92039, USA.ORCID 0000-0003-1152-1509
Tonking BastolaHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA.ORCID 0000-0002-3779-7178
Keun-Young KimNational Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA 92039, USA.
Sungsik ParkHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA.ORCID 0000-0001-9553-3202
Yury I MillerDepartment of Medicine, University of California San Diego, La Jolla, CA 92039, USA.
Won-Kyu JuHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA.ORCID 0000-0003-1117-4834

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Radha Ayyagari · 2012 to 2026
$10.3M
Reversing Microglial Inflammarafts and Mitochondrial Dysfunction in Alzheimer's DiseaseR01AG081037 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark H Ellisman, WONKYU JU · 2023 to 2026
$3.1M
Mitochondrial Protection in Glaucomatous Optic NeuropathyR01EY031697 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JU, WONKYU, PERKINS, GUY A · 2020 to 2023
$2.7M
AIBP-mediated neuroprotection in glaucomatous optic neuropathyR01EY034116 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SOO-HO CHOI, WONKYU JU · 2023 to 2026
$2.6M
Macrophage Inflammarafts and Mitochondrial Dysfunction in AtherosclerosisR01HL171505 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yury Miller · 2024 to 2026
$2.3M
Development of AAV-AIBP for neuroprotection in glaucomaUG3NS129684 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JU, WONKYU · 2023 to 2024
$835k
AAV-AIBP Therapy for Alzheimer's DiseaseR41AG081004 · NIA · RAFT PHARMACEUTICALS, LLC · PI JU, WONKYU, KOGAN, YAKOV · 2022 to 2023
$500k
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY031697NEI NIH HHS R01 EY034116NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL171505NIA NIH HHS R01 AG081037NIA NIH HHS R41 AG081004NIH HHS EY031697, EY034116, NS129684, AG081004, EY022589, HL136275, HL171505 and AG081037NINDS NIH HHS UG3 NS129684
6 · The paper itself

Abstract

Glaucoma, an optic neuropathy with the loss of retinal ganglion cells (RGCs), is a leading cause of irreversible vision loss. Oxidative stress and mitochondrial dysfunction have a significant role in triggering glia-driven neuroinflammation and subsequent glaucomatous RGC degeneration in the context of glaucoma. It has previously been shown that apolipoprotein A-I binding protein (APOA1BP or AIBP) has an anti-inflammatory function. Moreover,

Indexed as

AIBPglaucomamitochondriaMüller glianeuroinflammationoxidative stressretinal ganglion cells

Identifiers

PMID39456505
PMCPMC11505583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.