Evidence map›Paper›PMID 39456499›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner.

Na Liu, Xin Cui, Tingli Guo, Xiaotong Wei, Yuzhuo Sun, Jieyun Liu, Yangyang Zhang, Weina Ma, Wenhui Yan, Lina Chen

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Na LiuDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Xin CuiDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Tingli GuoDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Xiaotong WeiDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Yuzhuo SunDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Jieyun LiuDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Yangyang ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Weina MaSchool of Pharmacy, Xi'an Jiaotong University, Xi'an 710049, China.
Wenhui YanDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Lina ChenDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.

Funding

Basic & Clinical Sciences Integration Innovation Project of Xi'an Jiaotong University YXJLRH2022018National Natural Science Foundation of China 82301365Natural Science Basic Research Program of Shaanxi Province 2023-JC-QN-0921;2023-JC-ZD-47Research Project of Shaanxi Administration of Traditional Chinese Medicine SZY-KJCYC-2023-008
6 · The paper itself

Abstract

Insulin resistance (IR) is the principal pathophysiological change occurring in diabetes mellitus (DM). Baicalein, a bioactive flavonoid primarily extracted from the medicinal plant

Indexed as

baicaleinCa2+GLP-1Rinsulin resistancePI3K-AKT

Identifiers

PMID39456499
PMCPMC11505556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.