Evidence map›Paper›PMID 39456479›Full record

ArticleAntioxidants (Basel, Switzerland)2024

PET Imaging with [

Yi Zhu, Neha Kohli, Anthony Young, Malkah Sheldon, Jani Coni, Meera Rajasekaran, Lozen Robinson, Rea Chroneos, Shaipreeah Riley, Joseph W Guarnieri and 7 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yi ZhuDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0009-0002-1495-7535
Neha KohliDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Anthony YoungDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Malkah SheldonDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jani ConiDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Meera RajasekaranDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0009-0006-1138-5518
Lozen RobinsonDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Rea ChroneosDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Shaipreeah RileyDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Joseph W GuarnieriCenter for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Joshua JoseDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0009-0007-3123-7536
Nisha PatelDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0009-0008-9964-2826
Douglas C WallaceCenter for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Shihong LiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hsiaoju LeeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Robert H MachDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7645-2869
Meagan J McManusDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Funding

Role of Adaptive Immunity in Etiology of Alzheimer’s Disease andAlzheimer’s Disease-Related DementiasR01AG078814 · NIA · CHILDREN'S HOSP OF PHILADELPHIA · PI Douglas C Wallace · 2022 to 2026
$4.2M
Anti-tumor immunity and intestinal microbiota are modulated by mitochondrial DNAR01CA259635 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Douglas C Wallace · 2022 to 2026
$3.2M
Superoxide-sensitive radiotracer as a predictive biomarker of Parkinson's disease progressionR01NS114656 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI MCMANUS, MEAGAN JOY · 2020 to 2024
$2.6M
NCI NIH HHS R01 CA259635NIA NIH HHS R01 AG078814NIH NINDS R01NS114656NINDS NIH HHS R01 NS114656
6 · The paper itself

Abstract

Although the precise molecular mechanisms responsible for neuronal death and motor dysfunction in late-onset Parkinson's disease (PD) are unknown, evidence suggests that mitochondrial dysfunction and neuroinflammation occur early, leading to a collective increase in reactive oxygen species (ROS) production and oxidative stress. However, the lack of methods for tracking oxidative stress in the living brain has precluded its use as a potential biomarker. The goal of the current study is to address this need through the evaluation of the first superoxide (O

Indexed as

mitochondriaMitoPark mouse modelneurodegenerative diseaseneuroinflammationoxidative stresspositron emission tomography (PET)reactive oxygen species (ROS)

Identifiers

PMID39456479
PMCPMC11504722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.