Evidence map›Paper›PMID 39456450›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Synthesis and Biological Activity Assessment of 2-Styrylbenzothiazoles as Potential Multifunctional Therapeutic Agents.

Riccardo Barbari, Vera Bruggink, Robert Klaus Hofstetter, Chiara Tupini, Sofia Fagnani, Erika Baldini, Elisa Durini, Ilaria Lampronti, Silvia Vertuani, Anna Baldisserotto and 2 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Riccardo BarbariDepartment of Life Science and Biotechnology, Section of Medicines and Health Products, University of Ferrara, Via Fossato di Mortara 17-19, I-44121 Ferrara, Italy.ORCID 0000-0002-1267-0656
Vera BrugginkDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.
Robert Klaus HofstetterDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0002-1077-9703
Chiara TupiniDepartment of Life Science and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara 74, I-44121 Ferrara, Italy.ORCID 0000-0003-2340-0552
Sofia FagnaniDepartment of Life Science and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara 74, I-44121 Ferrara, Italy.
Erika BaldiniDepartment of Life Science and Biotechnology, Section of Medicines and Health Products, University of Ferrara, Via Fossato di Mortara 17-19, I-44121 Ferrara, Italy.ORCID 0009-0001-2307-8877
Elisa DuriniDepartment of Life Science and Biotechnology, Section of Medicines and Health Products, University of Ferrara, Via Fossato di Mortara 17-19, I-44121 Ferrara, Italy.ORCID 0000-0003-4430-8958
Ilaria LamprontiDepartment of Life Science and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara 74, I-44121 Ferrara, Italy.ORCID 0000-0002-1972-7766
Silvia VertuaniDepartment of Life Science and Biotechnology, Section of Medicines and Health Products, University of Ferrara, Via Fossato di Mortara 17-19, I-44121 Ferrara, Italy.
Anna BaldisserottoDepartment of Life Science and Biotechnology, Section of Medicines and Health Products, University of Ferrara, Via Fossato di Mortara 17-19, I-44121 Ferrara, Italy.ORCID 0000-0002-2882-3530
Oliver WerzDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0002-5064-4379
Stefano ManfrediniDepartment of Life Science and Biotechnology, Section of Medicines and Health Products, University of Ferrara, Via Fossato di Mortara 17-19, I-44121 Ferrara, Italy.ORCID 0000-0003-1348-4422

Funding

PRIN 2017 2017E84AA4_002
6 · The paper itself

Abstract

A current trend in healthcare research is to discover multifunctional compounds, able to interact with multiple biological targets, in order to simplify multi-drug therapies and improve patient compliance. The aim of this work was to outline the growing demand for innovative multifunctional compounds, achieved through the synthesis, characterisation and SAR evaluation of a series of 2-styrylbenzothiazole derivatives. The six synthesised compounds were studied for their potential as photoprotective, antioxidant, antiproliferative, and anti-inflammatory agents. In order to profile antioxidant activity against various radical species, in vitro DPPH, FRAP and ORAC assays were performed. UV-filtering activity was studied, first in solution and then in formulation (standard O/W sunscreen containing 3% synthesised molecules) before and after irradiation. Compound

Indexed as

ant-inflammatoryantioxidantsantitumorbenzothiazole derivativesmultifunctional

Identifiers

PMID39456450
PMCPMC11504387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.