Evidence map›Paper›PMID 39456336›Full record

ArticleFoods (Basel, Switzerland)2024

Dual Functionality of Papaya Leaf Extracts: Anti-Coronavirus Activity and Anti-Inflammation Mechanism.

Yujia Cao, Kah-Man Lai, Kuo-Chang Fu, Chien-Liang Kuo, Yee-Joo Tan, Liangli Lucy Yu, Dejian Huang

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Biochemistry and biophysics reports · 2026
    Article
  2. Itching, Ionic Channels, Immune System, Magnesium and Antioxidants.Clinical, cosmetic and investigational dermatology · 2026
    Review
  3. Various parts ofFrontiers in molecular biosciences · 2026
    Review
  4. The Anti-Inflammatory and Skin Barrier Function Recovery Effects ofInternational journal of molecular sciences · 2025
    Article
  5. International journal of molecular sciences · 2025
    Article
  6. Article
  7. Synergistic Effects of Carrot (Food science & nutrition · 2025
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yujia CaoDepartment of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore.ORCID 0000-0001-9984-3080
Kah-Man LaiInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
Kuo-Chang FuAgriGADA Biotech Pte Ltd., 8 Eu Tong Sen Street #17-82, The Central, Singapore 059818, Singapore.
Chien-Liang KuoAgriGADA Biotech Pte Ltd., 8 Eu Tong Sen Street #17-82, The Central, Singapore 059818, Singapore.
Yee-Joo TanInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.ORCID 0000-0002-2278-4497
Liangli Lucy YuDepartment of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0001-6497-0864
Dejian HuangDepartment of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore.

Funding

Singapore Ministry of Education A collaborative project between NUS and AgriGADA Pte Ltd.Singapore Ministry of Education Scholarship to Yujia CaoSingapore Ministry of Education T2EP30121-0012
6 · The paper itself

Abstract

Papaya leaves have been used as food and traditional herbs for the treatment of cancer, diabetes, asthma, and virus infections, but the active principle has not been understood. We hypothesized that the anti-inflammatory activity could be the predominant underlying principle. To test this, we extracted papaya leaf juice with different organic solvents and found that the ethyl acetate (EA) fraction showed the most outstanding anti-inflammatory activity by suppressing the production of nitric oxide (NO, IC

Indexed as

anti-coronavirusanti-inflammationCOVID-19papaya leavessynergistic effect

Identifiers

PMID39456336
PMCPMC11506937

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.