Evidence map›Paper›PMID 39456258›Full record

ArticleBiomolecules2024

Endometrial Dysbiosis: A Possible Association with Estrobolome Alteration.

Giorgia Scarfò, Simona Daniele, Elisa Chelucci, Francesca Papini, Francesco Epifani, Maria Ruggiero, Vito Cela, Ferdinando Franzoni, Paolo Giovanni Artini

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giorgia ScarfòDivision of General Medicine, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Simona DanieleDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-7391-3087
Elisa ChelucciDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Francesca PapiniDivision of Gynecology and Obstetrics, Azienda Ospedaliero Universitaria Pisana and Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Francesco EpifaniDepartment of Juridical and Economic Sciences, Pegaso Telematic University, 80143 Napoli, Italy.
Maria RuggieroSan Rossore Clinic Care, 56100 Pisa, Italy.
Vito CelaDivision of Gynecology and Obstetrics, Azienda Ospedaliero Universitaria Pisana and Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Ferdinando FranzoniDivision of General Medicine, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-2132-8788
Paolo Giovanni ArtiniDivision of Gynecology and Obstetrics, Azienda Ospedaliero Universitaria Pisana and Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7164-0553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesMicrobiota modification at the endometrial level can favor gynecological diseases and impair women's fertility. The overgrowth of pathogen microorganisms is related to the contemporary alteration of estrogen-metabolizing bacteria, including β-glucuronidase, thereby enhancing estrogen-related inflammatory states and decreasing anti-inflammatory cells. The possible connection between estrobolome impairment and gynecological diseases has been suggested in animal models. Nevertheless, in humans, coherent evidence on the estrobolome alteration and functionality of the female reproductive tract is still lacking. The objective of this study was to explore alterations in estrogen-related signaling and the putative link with endometrial dysbiosis.

methodsWomen with infertility and repeated implantation failure (RIF, N = 40) were enrolled in order to explore the putative link between estrogen metabolism and endometrial dysbiosis. Endometrial biopsies were used to measure inflammatory and growth factor molecules. β-glucuronidase enzyme activity and estrogen receptor (ER) expression were also assessed.

resultsHerein, increased levels of inflammatory molecules (i.e., IL-1β and HIF-1α) and decreased levels of the growth factor IGF-1 were found in the endometrial biopsies of patients presenting dysbiosis compared to eubiotic ones. β-glucuronidase activity and the expression of ERβ were significantly enhanced in patients in the dysbiosis group. Interestingly, Lactobacilli abundance was inversely related to β-glucuronidase activity and to ERβ expression, thus suggesting that an alteration of the estrogen-activating enzyme may affect the expression of ERs as well.

conclusionsOverall, these preliminary data suggested a link between endometrial dysbiosis and estrobolome impairment as possible synergistic contributing factors to women infertility and RIF.

Indexed as

DysbiosisEndometriumAdultEstrogen Receptor betaEstrogensFemaleGlucuronidaseHumansHypoxia-Inducible Factor 1, alpha SubunitInfertility, FemaleInsulin-Like Growth Factor IInterleukin-1betaEstrogen Receptor betaEstrogensGlucuronidaseHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIGF1 protein, humanInsulin-Like Growth Factor IInterleukin-1betaendometrial dysbiosisestrobolomeinflammationwomen infertility

Identifiers

PMID39456258
PMCPMC11506823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.