Evidence map›Paper›PMID 39456200›Full record

ArticleBiomolecules2024

MGACL: Prediction Drug-Protein Interaction Based on Meta-Graph Association-Aware Contrastive Learning.

Pinglu Zhang, Peng Lin, Dehai Li, Wanchun Wang, Xin Qi, Jing Li, Jianshe Xiong

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pinglu ZhangFaculty of Information Science and Engineering, Ocean University of China, Qingdao 266003, China.
Peng LinKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0009-0009-3398-8864
Dehai LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0000-0002-7191-2002
Wanchun WangFaculty of Information Science and Engineering, Ocean University of China, Qingdao 266003, China.
Xin QiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Jing LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Jianshe XiongFaculty of Information Science and Engineering, Ocean University of China, Qingdao 266003, China.

Funding

Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City 2021CXLH0012Shandong Provincial Natural Science Foundation ZR2021ZD28Shandong Provincial Natural Science Foundation ZR2022MH083
6 · The paper itself

Abstract

The identification of drug-target interaction (DTI) is crucial for drug discovery. However, how to reduce the graph neural network's false positives due to its bias and negative transfer in the original bipartite graph remains to be clarified. Considering that the impact of heterogeneous auxiliary information on DTI varies depending on the drug and target, we established an adaptive enhanced personalized meta-knowledge transfer network named

Indexed as

Drug DiscoveryAlgorithmsArea Under CurveHumansMachine LearningNeural Networks, ComputerPharmaceutical PreparationsProteinsPharmaceutical PreparationsProteinscontrastive learningdrug–target interactiongraph neural networksheterogeneous graph representation

Identifiers

PMID39456200
PMCPMC11505808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.