Evidence map›Paper›PMID 39456190›Full record

ArticleBiomolecules2024

Compound K Promotes Megakaryocytic Differentiation by NLRP3 Inflammasome Activation.

Seonhwa Hwang, Min-Seo Park, Anthony Junhoe Koo, Eunsoo Yoo, Seh-Hyon Song, Hye-Kyung Kim, Min-Hi Park, Jae-Seon Kang

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seonhwa HwangCollege of Pharmacy, Kyungsung University, 309 Suyeong-ro, Busan 48434, Republic of Korea.ORCID 0000-0001-8943-1840
Min-Seo ParkCollege of Pharmacy, Kyungsung University, 309 Suyeong-ro, Busan 48434, Republic of Korea.
Anthony Junhoe KooCollege of Engineering, North Carolina A&T State University, Greensboro, NC 27411, USA.ORCID 0009-0009-4252-3524
Eunsoo YooChemical, Biological, and Bioengineering Department, North Carolina A&T State University, Greensboro, NC 27411, USA.ORCID 0000-0002-1085-8751
Seh-Hyon SongCollege of Pharmacy, Kyungsung University, 309 Suyeong-ro, Busan 48434, Republic of Korea.
Hye-Kyung KimCollege of Pharmacy, Kyungsung University, 309 Suyeong-ro, Busan 48434, Republic of Korea.
Min-Hi ParkCollege of Pharmacy, Kyungsung University, 309 Suyeong-ro, Busan 48434, Republic of Korea.
Jae-Seon KangCollege of Pharmacy, Kyungsung University, 309 Suyeong-ro, Busan 48434, Republic of Korea.

Funding

Ministry of Health & Welfare, Republic of Korea HR20C0023National Research Foundation of Korea (NRF) 2021R1I1A3061377
6 · The paper itself

Abstract

Platelets are essential blood components that maintain hemostasis, prevent excessive bleeding, and facilitate wound healing. Reduced platelet counts are implicated in various diseases, including leukemia, hepatitis, cancer, and Alzheimer's disease. Enhancing megakaryocytic differentiation is a promising strategy to increase platelet production. Compound K (CK), a major bioactive metabolite of ginsenosides from

Indexed as

ApoptosisCell DifferentiationGinsenosidesInflammasomesMegakaryocytesNLR Family, Pyrin Domain-Containing 3 ProteinHumansIntegrin beta3K562 CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositivePlatelet Membrane Glycoprotein IIbginsenoside compound KGinsenosidesInflammasomesIntegrin beta3ITGB3 protein, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPlatelet Membrane Glycoprotein IIbcompound Kleukemia cellmegakaryocytic differentiationNLRP3 inflammasomeplatelets

Identifiers

PMID39456190
PMCPMC11506438

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.