ArticleInternational journal of retina and vitreous2024
Safety and efficacy of human amniotic membrane plug transplantation in cases of macular hole. A scoping review.
Article in International journal of retina and vitreous, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Feasibility Study of Decellularized Corneal Lenticule in a Porcine Model for Macular Hole Closure.Ophthalmology and therapy · 2026Article
- Surgical Outcomes of Epiretinal Human Amniotic Membrane Transplantation for Refractory Macular Holes.Journal of clinical medicine · 2026Article
- Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases.Vision (Basel, Switzerland) · 2025Article
- Autologous Tenon's Capsule Graft for Recurrent Retinal Detachment Associated with a Cavitary Optic Disc Anomaly following Failed Amniotic Membrane Grafting.Journal of current ophthalmologyArticle
- Optical Coherence Tomography of a Folded Amniotic Membrane over a Macular Hole.Case reports in ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, there has been a surge of literature utilizing the human amniotic membrane (hAM) to manage cases of macular holes. In this scoping review, we aimed to systematically narrate the literature to identify cases of macular holes that are managed using hAM and explore the visual and anatomical outcomes to inform future research questions.
methodsThis scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A detailed database search strategy (Scopus, Embase, Medline, and Cochrane Central) was developed to identify English-language published articles that reported using hAM to manage macular holes. All human clinical studies were included for a narrative data synthesis divided across study types.
resultsThe database search identified 82 articles, of which 34 were eligible for full-text review (0 randomized controlled trials (RCTs), 12 non-RCTs, 10 retrospective reviews, ten published case reports, and two clinical trial registries). The non-RCTs included patients with macular holes related to a wide range of retinal diseases, including retinal detachment, recurrent holes, and high myopia. Only two non-RCTs reported comparative data with a control group, but the study characteristics differed, and quantitative synthesis was impossible. Most retrospective interventional series and individual case reports reported a success rate of 93 -100% in hole closure and improvement in best-corrected visual acuity. None of the studies reported adverse effects after a hAM transplantation.
conclusionThe hAM effectively seals macular holes without any safety concerns, improving anatomical and visual outcomes in all macular holes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.