Evidence map›Paper›PMID 39456013›Full record

ArticleBMC pediatrics2024

Identifying distinct phenotypes of patients with juvenile systemic lupus erythematosus: results from a cluster analysis by the Egyptian college of rheumatology (ECR) study group.

Nevin Hammam, Tamer A Gheita, Ali Bakhiet, Mohamed Bakry Mahmoud, Rasha El Owaidy, Hend Abdel Nabi, Ahmed M Elsaman, Iman Khalifa, Abeer M Nour ElDin Abd ElBaky, Faten Ismail and 12 more

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Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

22 authors.

Nevin HammamRheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt. nevin.hammam@gmail.com.
Tamer A GheitaRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ali BakhietComputer Science Department, Higher Institute of Computer Science and Information Systems, Culture and Science City, Giza, Egypt.
Mohamed Bakry MahmoudComputer Science Department, Higher Institute of Computer Science and Information Systems, Culture and Science City, Giza, Egypt.
Rasha El OwaidyPediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Hend Abdel NabiPediatrics Department, Rheumatology and Nephrology Unit, Tanta University, Gharbia, Egypt.
Ahmed M ElsamanRheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Iman KhalifaPediatrics Unit, Helwan University, Cairo, Egypt.
Abeer M Nour ElDin Abd ElBakyPediatrics Department, Medical Research and Clinical Studies Institute, National Research Centre (NRC), Cairo, Egypt.
Faten IsmailRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Eman HassanInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Rawhya R El ShereefRheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Iman I El-GazzarRheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abdelhfeez MoshrifInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Noha M KhalilInternal Medicine Department, Rheumatology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.
Marwa A AmerRheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Hanan M FathyPediatrics Nephrology Unit, Alexandria University, Alexandria, Egypt.
Nancy Abdel SalamPediatrics Nephrology Unit, Alexandria University, Alexandria, Egypt.
Mervat I Abd ElazeemRheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Osman HammamDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, New Valley University, New Valley, Egypt.
Hanan M FathiRheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Samar TharwatInternal Medicine, Rheumatology Unit, Mansoura University, Dakahlia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeJuvenile systemic lupus erythematosus (J-SLE) is a complex, heterogeneous disease affecting multiple organs. However, the classification of its subgroups is still debated. Therefore, we investigated the aggregated clinical features in patients with J-SLE using cluster analysis.

methodsPatients (≤ 16 years) diagnosed using the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria were identified from the clinical database of the Egyptian College of Rheumatology (ECR) SLE study group. Demographic data, clinical characteristics, laboratory features, and current therapies were selected. A cluster analysis was performed to identify different clinical phenotypes.

resultsOverall, 404 patients, of whom 355 (87.9%) were female, had a mean age at diagnosis of 11.2 years and a mean disease duration of 2.3 years. We identified four distinct subsets of patients. Patients in cluster 1 (n = 103, 25.5%) were characterized predominantly by mucocutaneous and neurologic manifestations. Patients in cluster 2 (n = 101, 25%) were more likely to have arthritis and pulmonary manifestations. Cluster 3 (n = 71, 17.6%) had the lowest prevalence of arthritis and lupus nephritis (LN), indicative of mild disease intensity. Patients in cluster 4 (n = 129, 31.9%) have the highest frequency of arthritis, vasculitis, and LN. Cluster 1 and 4 patients had the highest disease activity index score and were less likely to use low-dose aspirin (LDA). The SLE damage index was comparable across clusters.

conclusionsFour identified J-SLE clusters express distinct clinical phenotypes. Attention should be paid to including LDA in the therapeutic regimen for J-SLE. Further work is needed to replicate and clarify the phenotype patterns in J-SLE.

Indexed as

Lupus Erythematosus, SystemicPhenotypeAdolescentChildCluster AnalysisEgyptFemaleHumansMaleCluster analysisJuvenile systemic lupus erythematosusMachine learning

Identifiers

PMID39456013
PMCPMC11515332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.