Evidence map›Paper›PMID 39455721›Full record

ArticleScientific reports2024

Quantitative detection of macular microvascular abnormalities identified by optical coherence tomography angiography in different hematological diseases.

Tianzi Jian, Fabao Xu, Guihua Li, Boxuan Song, Helei Wang, Xueying Yang, Weibin Zhai, Xiangchen Li, Zhiwen Li, Qi Feng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tianzi JianDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Fabao XuDepartment of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China. 517311823@qq.com.
Guihua LiZibo Central Hospital, Binzhou Medical University, Zibo, Shandong province, China.
Boxuan SongDepartment of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China.
Helei WangDepartment of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China.
Xueying YangDepartment of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China.
Weibin ZhaiDepartment of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China.
Xiangchen LiDepartment of Computer Science, the University of Manchester, Manchester, UK.
Zhiwen LiDepartment of Ophthalmology, Qilu Hospital, Shandong University, Jinan, China.
Qi FengDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
Shuqian XuDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China.
John W SempleDivision of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.
Li ZhangDepartment of Ophthalmology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, Hubei, China. 254843236@qq.com.
Jun PengDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, China. junpeng88@sina.com.

Funding

Natural Science Foundation for Young Scholars of Shandong Province of China ZR202111120236Novo Nordisk Haemophilia Research Fund (NNHRF) China Clinical Research Center of Shandong University nos. 2020SDUCRCC015Shandong Province "Double-Hundred Talent Plan" on 100 Foreign Experts and 100 Foreign Expert Teams Introduction (For Team) WST2021004Shandong Provincial People's Government, Mount Taishan Scholar Young Expert tsqn202103167Youth Fund of the National Natural Science Foundation of China nos.81300383
6 · The paper itself

Abstract

It is now understood that hematological diseases can have detrimental effects on the retina, reducing retinal capillaries, compromising visual function, and potentially causing irreversible visual impairment. Over the years, there has been limited research on macular microvascular abnormalities, such as changes in vessel density and the foveal avascular zone (FAZ) and variations in the severity of these effects across different types of blood disorders. This study aims to quantitatively assess the impact of various hematological disorders on the retina using optical coherence tomography angiography (OCTA). Compared with healthy eyes, patients with different blood diseases exhibited reductions in linear vessel density (LVD), perfusion vessel density (PVD), FAZ area, and FAZ perimeter. Notably, patients with erythrocyte diseases showed more significant abnormalities in LVD and PVD, while patients with lymphocytic diseases demonstrated more pronounced abnormalities in the FAZ area and perimeter. OCTA imaging could potentially reflect changes of the retinal microvascular of patients with hematological diseases and may serve as a valuable tool for distinguishing abnormalities affecting different blood cell lines. This approach offers a novel avenue for assessing, treating, and monitoring blood disorders.

Indexed as

Hematologic DiseasesRetinal VesselsTomography, Optical CoherenceAdultAgedFemaleFluorescein AngiographyHumansMacula LuteaMaleMicrovesselsMiddle AgedRetinal DiseasesErythrocyte diseasesLymphocyte diseasesMyelocyte diseasesOptical coherence tomography angiographyPancytopenia diseases

Identifiers

PMID39455721
PMCPMC11511973

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