ArticleNature biomedical engineering2024
Viscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies.
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Article in Nature biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Decoding mechanoregulation in immunological synapses using biomimetic artificial cells.Nature methods · 2026Article
- Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function.bioRxiv : the preprint server for biology · 2026Article
- A Microgel-Based Platform for Tunable Expansion and Function of γδ T-cells.bioRxiv : the preprint server for biology · 2026Article
- Mechanobiology of CAR-T cell therapy: regulatory mechanisms and strategies for enhanced antitumor immunity.Journal of translational medicine · 2026Review
- Manufacturing synthetic viscoelastic antigen-presenting cells for immunotherapy.Nature protocols · 2026Review
- Injectable and viscoelastic click alginate hydrogels for spatio-temporal T cell administration in vivo.Materials today. Bio · 2026Article
- Facile and Green Fabrication of Porous Hydrogels Based on Gelatin Microsphere Porogens for 3D Immune Cell Culture.Gels (Basel, Switzerland) · 2026Article
- Microfluidics for Blood Disorders and Hematological Disease Monitoring and Modeling.International journal of molecular sciences · 2026Review
- Aerogel-involved triple-state viscoelastic fluidic materials enable high-efficiency dual-purpose energy management.Nature communications · 2026Article
- A versatile nanoplatform for enhancing the therapeutic efficacy against low-immunogenic TNBC by inducing immunogenic cell death and MHC-I upregulation.Materials today. Bio · 2026Article
- Engineering an in vivo charging station for CAR-redirected invariant natural killer T cells to enhance cancer therapy.Nature biomedical engineering · 2026Article
- Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential.npj biomedical innovations · 2026Review
- Mechanobiological research fueling the advancement of mechanotherapy and mechanohealth.Mechanobiology in medicine · 2026Article
- Mechanomedicine.Nature reviews bioengineering · 2026Article
- Synergistic mechanical and therapeutic modulation of engineered tumor cell-derived microparticles for enhanced cancer treatment.Cell reports. Medicine · 2026Article
- Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Synthetic Cell-Based Tissues for Bottom-Up Assembly of Artificial Lymphatic Organs.Advanced healthcare materials · 2026Article
- Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy.Nature communications · 2026Article
- Mechanomedicine: Present state and future promise.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unlocking the therapeutic potential of cellular mechanobiology.Science advances · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
Zeyang Liu *Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Yan-Ruide Li *Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Youcheng Yang *Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Yu ZhuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Weihao YuanSection of Restorative Dentistry, School of Dentistry, University of California, Los Angeles, CA, USA.
Tyler HoffmanDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Yifan WuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Enbo ZhuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8600-8553
Jana ZarubovaDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9647-9997
Jun ShenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Haochen NanDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Kun-Wei YehDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Mohammad Mahdi Hasani-SadrabadiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Yichen ZhuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Ying FangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Xinyang GeDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Zhizhong LiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Jennifer SotoDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Tzung HsiaiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1734-0792
Lili YangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA. liliyang@ucla.edu.ORCID http://orcid.org/0000-0001-6568-0404
Song LiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA. songli@ucla.edu.ORCID http://orcid.org/0000-0002-4760-8828
Funding
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5MElectronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3MIntravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8MStem Cell-Engineered Invariant Natural Killer T Cells for Cancer TherapyDP2CA196335 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, LILI · 2014 to 2014
$2.3MIntegrating Volumetric Light-Field with Computational Fluid Dynamics to Study Myocardial Trabeculation and FunctionR01HL159970 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2021 to 2024
$2.0MRegulation of cell reprogramming by matrix stiffnessR01GM143485 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2021 to 2024
$1.3MUCLA and Caltech integrated Cardiovascular Medicine for Bioengineers (iCMB)T32HL144449 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, PAJUKANTA, PAIVI · 2020 to 2024
$1.2MNOVEL MRI STUDY--NEURONAL LOSS IN TRANSGENIC MICER03AG014169 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI GAO, JIA-HONG · 1996 to 1996
–California Institute for Regenerative Medicine (CIRM) DISC2-14169California Institute for Regenerative Medicine (CIRM) DISE2-11157NCI NIH HHS DP2 CA196335NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL129727NHLBI NIH HHS R01 HL149808NHLBI NIH HHS R01 HL159970NHLBI NIH HHS T32 HL144449NIGMS NIH HHS R01 GM143485U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM143485U.S. Department of Health & Human Services | National Institutes of Health (NIH) NHLBI T32HL144449U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL129727
Abstract
The use of synthetic antigen-presenting cells to activate and expand engineered T cells for the treatment of cancers typically results in therapies that are suboptimal in effectiveness and durability. Here we describe a high-throughput microfluidic system for the fabrication of synthetic cells mimicking the viscoelastic and T-cell-activation properties of antigen-presenting cells. Compared with rigid or elastic microspheres, the synthetic viscoelastic T-cell-activating cells (SynVACs) led to substantial enhancements in the expansion of human CD8
Indexed as
Antigen-Presenting CellsCD8-Positive T-LymphocytesAnimalsCell Line, TumorElasticityFemaleHumansImmunotherapy, AdoptiveLymphocyte ActivationLymphomaMiceNeoplasmsOvarian NeoplasmsReceptors, Chimeric AntigenViscosityXenograft Model Antitumor AssaysReceptors, Chimeric Antigen
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