Evidence map›Paper›PMID 39455637›Full record

ArticleScientific reports2024

Chemical composition, antioxidant, and enzyme inhibition activities of Crithmum maritimum essential oils: the first chemo-biological study for species grown in North Africa.

Ahmed Ismail, Fatma A El-Shibani, Hamdoon A Mohammed, Belal O Al-Najjar, Amany M Korkor, Abdulnaser Kh Abdulkarim, Rana Said, Suliman A Almahmoud, Ghassan M Sulaiman

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Food and waterborne parasitology · 2026
    Article
  2. Article
  3. Molecules (Basel, Switzerland) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed IsmailPharmacognosy Department, Faculty of Pharmacy, Fayoum University, Fayoum, 63514, Egypt. ais03@fayoum.edu.eg.ORCID 0000-0003-0266-8760
Fatma A El-ShibaniDepartment of Pharmacognosy, Faculty of Pharmacy, Benghazi University, Benghazi, Libya.
Hamdoon A MohammedDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, 51452, Buraydah, Qassim, Saudi Arabia.
Belal O Al-NajjarDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan.
Amany M KorkorPharmacognosy Department, Faculty of Pharmacy (Girls), AL-Azhar University, Cairo, Egypt.
Abdulnaser Kh AbdulkarimDepartment of Basic Medical Science, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.
Rana SaidDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan.
Suliman A AlmahmoudDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, 51452, Buraydah, Qassim, Saudi Arabia.
Ghassan M SulaimanDivision of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad, 10066, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crithmum maritimum (sea fennel), is a halophytic plant species found globally in coastal environments. This study is the first investigation into the chemical composition and biological activities of C. maritimum growing wildly in Jebel Akhdar, Libya. Gas Chromatography-Mass Spectrometry (GC-MS) analysis was utilized to identify and profile the plant's volatile components; it resulted in the identification of twenty-four components, representing 99.17% of the total peaks in the GC-MS chromatogram. The analysis revealed that thymyl methyl ether, γ-terpinene, and ledene oxide, were the major volatile constituents of the plant at relative percentage levels of 56.86, 16.17, and 4.32%, respectively. The analysis also indicated substantial variations in the volatile composition of C. maritimum Libyan species compared to those from various geographic regions. The plant's volatile oil quality was evaluated by investigating its in vitro antioxidant activity and the oil's ability to inhibit acetylcholinesterase (AChE) and tyrosinase enzymes. The oil markedly scavenged the free radicals and reduced the ferric ions in the DPPH and FRAP assays at levels of 34.30 ± 0.10 and 38.90 ± 0.51 Trolox equivalents, respectively. The plant's volatile oil has substantially reduced the AChE at the IC

Indexed as

AntioxidantsCholinesterase InhibitorsOils, VolatileAcetylcholinesteraseAfrica, NorthernGas Chromatography-Mass SpectrometryMolecular Docking SimulationAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsOils, VolatileAnti-acetylcholinesteraseAntioxidantsAnti-tyrosinaseCrithmum maritimumDocking analysisGC-MSHalophytesSee fennel

Identifiers

PMID39455637
PMCPMC11512020

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.