Evidence map›Paper›PMID 39455610›Full record

ArticleScientific reports2024

Impact of sarcopenia and fat distribution on outcomes in penile cancer.

Valerie Hartmann, Simon Udo Engelmann, Christoph Pickl, Maximilian Haas, Sebastian Kälble, Christopher Goßler, Christoph Eckl, Aybike Hofmann, Renate Pichler, Maximilian Burger and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Valerie HartmannDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Simon Udo EngelmannDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Christoph PicklDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Maximilian HaasDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Sebastian KälbleDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Christopher GoßlerDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Christoph EcklDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Aybike HofmannDepartment of Pediatric Urology, Clinic St. Hedwig, University Medical Center Regensburg, Regensburg, Germany.
Renate PichlerDepartment of Urology, Comprehensive Cancer Center, Medical University of Innsbruck, Innsbruck, Austria.
Maximilian BurgerDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany.
Roman MayrDepartment of Urology, St. Josef Medical Center, University Medical Center Regensburg, Regensburg, Germany. roman.mayr@ukr.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia, defined as age-associated loss of skeletal muscle function and muscle mass, is a negative prognostic marker for survival in several tumor entities. However, data evaluating the impact of sarcopenia and fat distribution on penile cancer are rarely described. We performed a retrospective study including 38 patients who were diagnosed with squamous cell carcinoma of the penis. By measuring skeletal muscle mass and fat distribution at axial abdominal computed tomography images at the third lumbar vertebra several body composition parameters including skeletal muscle index (SMI), psoas muscle index (PMI), visceral obesity and visceral-to-subcutaneous fat ratio were determined. Among 38 patients, 26% (n = 10) of the patients with penile cancer were identified as sarcopenic. SMI, age, lymph node metastases, distant metastases and penile cancer of the shaft were identified as significant risk factors for overall survival. PMI and distant metastases were significantly associated with cancer specific survival. None of the analysed adipose tissue parameters could be identified as risk factors for survival in this study. We showed that sarcopenia occurs in a relevant part of patients with penile cancer and is a significant risk factor for overall survival (p = 0.032) and cancer specific survival (p = 0.034) for patients with penile cancer. Regarding fat distribution further studies are needed to evaluate its impact on sarcopenia and survival.

Indexed as

Penile NeoplasmsSarcopeniaAdipose TissueAgedAged, 80 and overBody CompositionBody Fat DistributionCarcinoma, Squamous CellHumansMaleMiddle AgedMuscle, SkeletalPrognosisRetrospective StudiesRisk FactorsTomography, X-Ray ComputedBody compositionPsoas muscle indexSkeletal muscle indexSquamous carcinomaVisceral obesity

Identifiers

PMID39455610
PMCPMC11512017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.