Evidence map›Paper›PMID 39455572›Full record

Trial reportNutrition & diabetes2024

Late eating is associated with poor glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 diabetes.

Diana A Díaz-Rizzolo, Leinys S Santos Baez, Collin J Popp, Rabiah Borhan, Ana Sordi-Guth, Emily N C Manoogian, Satchidananda Panda, Bin Cheng, Blandine Laferrère

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrition & diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04465721 (New York TREAT), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04465721 nacompletednot on this map

New York TREAT (Time Restricted EATing) to Improve Cardiometabolic Health Study

TypeinterventionalSponsorColumbia UniversityRan2021 to 2026Enrolled57ConditionsOverweight and Obesity, PrediabetesArmsTRE, HABIT
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Circadian nutrition and obesity: timing as a nutritional strategy.Journal of health, population, and nutrition · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana A Díaz-RizzoloDivision of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA.
Leinys S Santos BaezDivision of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA.
Collin J PoppDepartment of Population Health, New York Langone Health Grossman School of Medicine, New York, NY, USA.
Rabiah BorhanDivision of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA.
Ana Sordi-GuthDivision of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA.
Emily N C ManoogianSalk Institute for Biological Studies, Regulatory Biology Laboratory, La Jolla, CA, USA.ORCID 0000-0001-9718-9310
Satchidananda PandaSalk Institute for Biological Studies, Regulatory Biology Laboratory, La Jolla, CA, USA.
Bin ChengDepartment of Biostatistics, Columbia University Irving Medical Center, New York, NY, USA.
Blandine LaferrèreDivision of Endocrinology, Nutrition Obesity Research Center, Diabetes Research Center Columbia University Irving Medical Center, New York, NY, USA. bbl14@columbia.edu.ORCID 0000-0001-8255-3175

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
TREAT (Time Restricted EATing) to improve cardiometabolic healthR01AG065569 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAFERRERE, BLANDINE B · 2020 to 2024
$3.9M
Personalized Dietary Management in Type 2 DiabetesR01NR018916 · NINR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POPP, COLLIN JEFFREY, SEGAL, ERAN · 2021 to 2025
$3.5M
Time-restricted eating: Is it an efficacious tool for weight loss maintenanceK99HL163474 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POPP, COLLIN JEFFREY · 2023 to 2024
$297k
NCATS NIH HHS UL1 TR001873NHLBI NIH HHS K99 HL163474NIA NIH HHS R01 AG065569NINR NIH HHS R01 NR018916
6 · The paper itself

Abstract

This study investigates the impact of habitual late calorie intake on glucose metabolism in adults with overweight or obesity and diet or metformin-controlled prediabetes or type 2 diabetes independently of body weight, fat mass, energy intake or diet composition. Participants (n = 26) were classified as Later Eaters (LE) if ≥45% daily calories were consumed after 5 pm and Early Eaters (EE) if not, based on daily caloric intake assessed over 2-wk. EE and LE did not differ in anthropometrics or daily energy intake, but LE consumed more carbohydrates (p = 0.038) and fats (p = 0.039) after 5 pm. Fasting glucose, insulin, and C-peptide did not differ between groups but LE exhibited higher glucose concentrations after an oral glucose tolerance test (p = 0.001), even after adjusting for body weight, fat mass, energy intake and diet composition (p < 0.05). Glucose results remained when participants with T2D were excluded (p = 0.031). After diabetes status adjustment, differences in glucose concentrations were higher in LE for time 30 (p = 0.028) and 60 min (p = 0.036). LE, compared to EE, had poorer glucose tolerance, independent of body weight, fat mass, daily energy intake and diet composition. ClinicalTrials.gov: NCT04465721.

Indexed as

Blood GlucoseBody WeightDiabetes Mellitus, Type 2Energy IntakePrediabetic StateAdultDietFeeding BehaviorFemaleGlucose IntoleranceGlucose Tolerance TestHumansInsulinMaleMiddle AgedObesityBlood GlucoseInsulin

Identifiers

PMID39455572
PMCPMC11511895

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.