Evidence map›Paper›PMID 39454357›Full record

ArticleEcotoxicology and environmental safety2024

Ambient air pollution exposure is associated with liver fat and stiffness in Latino youth with a more pronounced effect in those with PNPLA3 genotype and more advanced liver disease.

Rachel B Schenker, Christopher J Machle, Hooman Allayee, Fredrick Lurmann, William B Patterson, Rohit Kohli, Michael I Goran, Tanya L Alderete

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ecotoxicology and environmental safety, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel B SchenkerDepartment of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA, USA. Electronic address: Rschenker@chla.usc.edu.
Christopher J MachleDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA; Department of Psychology, University of Oregon, Eugene, OR, USA. Electronic address: Cmachle@chla.usc.edu.
Hooman AllayeeDepartments of Population & Public Health Sciences and Biochemistry & Molecular Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: hallayee@usc.edu.
Fredrick LurmannSonoma Technology Inc., Petaluma, CA, USA. Electronic address: fred@sonomatech.com.
William B PattersonDepartment of Integrative Physiology, University of Colorado at Boulder, Boulder, CO, USA. Electronic address: William.patterson-1@colorado.edu.
Rohit KohliDepartment of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA, USA. Electronic address: Rokohli@chla.usc.edu.
Michael I GoranDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA. Electronic address: Goran@usc.edu.
Tanya L AldereteDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: taldere1@jhu.edu.

Funding

Southern California Center for Chronic Health Disparities in Latino Children and Families.P50MD017344 · NIMHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BOUTELLE, KERRI N · 2021 to 2025
$27.8M
Nutrigenetic Intervention to Reduce Liver Fat in Hispanics - SupplementR01MD010358 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC · 2016 to 2019
$3.3M
Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic ChildrenR01ES035035 · NIEHS · UNIVERSITY OF COLORADO · PI Tanya Lynn Alderete · 2023 to 2026
$2.6M
Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-ChildhoodR01ES035056 · NIEHS · UNIVERSITY OF COLORADO · PI Tanya Lynn Alderete, BRADLEY S PETERSON · 2024 to 2026
$2.1M
Translational Research Training in HepatologyT32DK127977 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Rohit Kohli, Norah A. Terrault · 2022 to 2026
$1.3M
Exposure to Ambient Air Pollutants, Circulating microRNAs, and Hepatic Fat Fraction Among Young AdultsF31DK134198 · NIDDK · UNIVERSITY OF COLORADO · PI PATTERSON, WILLIAM BROOKS · 2022 to 2023
$80k
NIDDK NIH HHS F31 DK134198NIDDK NIH HHS T32 DK127977NIEHS NIH HHS R01 ES035035NIEHS NIH HHS R01 ES035056NIMHD NIH HHS P50 MD017344NIMHD NIH HHS R01 MD010358
6 · The paper itself

Abstract

backgroundExposure to ambient air pollutants has emerged as a risk for metabolic-dysfunction associated steatotic liver disease (MASLD).

objectivesWe sought to examine associations between short-term (prior month) and long-term (prior year) ambient air pollution exposure with hepatic fat fraction (HFF) and liver stiffness in Latino youth with obesity. A secondary aim was to investigate effect modification by patatin-like phospholipase domain-containing protein 3 (PNPLA3) genotype and liver disease severity.

methodsData was analyzed from 113 Latino youth (age 11-19) with obesity in Southern California. Individual exposure to particulate matter with aerodynamic diameter ≤ 2.5μm (PM

resultsShort-term exposure to 8hrMax-O DISCUSSION: Air pollution exposure may be a risk factor for liver disease among Latino youth with obesity, particularly in those with other preexisting risks for liver damage.

Indexed as

Air PollutantsEnvironmental ExposureHispanic or LatinoLiverParticulate MatterAcyltransferasesAdolescentAir PollutionCaliforniaChildFatty LiverFemaleGenotypeHumansLiver DiseasesMaleAcyltransferasesAir PollutantsMembrane ProteinsNitrogen DioxideOzoneParticulate MatterPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanAir pollutionMASLDMetabolic-dysfunction association steatotic liver diseaseOzone

Identifiers

PMID39454357
PMCPMC11578286

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.