Evidence map›Paper›PMID 39454324›Full record

ArticleSchizophrenia research2024

Aberrant salience signaling in auditory processing in schizophrenia: Evidence for abnormalities in both sensory processing and emotional reactivity.

Mahima Dewan, Emily Campbell Daniels, Jared E Hunt, Emily A Bryant, Samantha I Trikeriotis, Deanna L Kelly, Heather A Adams, Stephanie M Hare, James A Waltz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahima DewanUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Emily Campbell DanielsUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Jared E HuntUniversity of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA.
Emily A BryantUniversity of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA.
Samantha I TrikeriotisUniversity of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA.
Deanna L KellyUniversity of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA; Spring Grove Hospital Center, Catonsville, MD, USA.
Heather A AdamsUniversity of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA; Spring Grove Hospital Center, Catonsville, MD, USA.
Stephanie M HareUniversity of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA.
James A WaltzUniversity of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA. Electronic address: jwaltz@som.umaryland.edu.

Funding

Reward System Function as a Potential Mediator of the Impact of Stress on Psychopathology: A Computational Neuroimaging StudyR01MH115031 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI WALTZ, JAMES A · 2018 to 2022
$2.6M
NIMH NIH HHS R01 MH115031
6 · The paper itself

Abstract

It has been long known that people with schizophrenia (SZ) have deficits in perceptual processing, including in the auditory domain. Furthermore, they often experience increased emotional responsivity and dysregulation, which further impacts overall functioning. Increased emotional responsivity to auditory stimuli is also seen in people with misophonia, a condition in which specific sounds elicit robust negative emotional responses. Given the role of emotional reactivity and dysregulation in the pathogenesis of SZ, our study investigated whether misophonia symptoms were elevated in SZ, or if people with SZ have a generalized increase in reactivity to sensory information. To explore the link between emotional reactivity to sound and more general aspects emotional reactivity and salience signaling in SZ, we used the Misophonia Questionnaire, the Sensory Processing Scale (SPS), and Aberrant Salience Inventory (ASI) in 30 people with SZ and 28 demographically-matched healthy volunteers (HVs). We found that people with SZ exhibited more emotional behavior associated with misophonia symptoms (specifically, distress in relation to sound) than HVs (t

Indexed as

Auditory PerceptionEmotionsSchizophreniaAcoustic StimulationAdultFemaleHumansMaleMiddle AgedSchizophrenic PsychologyYoung AdultAberrant salience inventoryHallucinationsMisophoniaPsychosisSensory processing scale

Identifiers

PMID39454324
PMCPMC11620929

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.