Evidence map›Paper›PMID 39454183›Full record

ArticleMolecular pharmaceutics2024

New Insights on the Burst Release Kinetics of Spray-Dried PLGA Microspheres.

Kyprianos Michaelides, Mohamad Anas Al Tahan, Yundong Zhou, Gustavo F Trindade, David J H Cant, Yiwen Pei, Pawan Dulal, Ali Al-Khattawi

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. How PLGA Microspheres are Emerging as a Key Drug Delivery System.International journal of nanomedicine · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Poly(lactic-ACS biomaterials science & engineering · 2025
    Article
  11. PLGA-based long-acting injectable (LAI) formulations.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kyprianos MichaelidesSchool of Pharmacy, Aston University, Birmingham B4 7ET, U.K.ORCID 0009-0001-9278-9226
Mohamad Anas Al TahanSchool of Pharmacy, Aston University, Birmingham B4 7ET, U.K.
Yundong ZhouChemical and Biological Sciences Department, National Physical Laboratory, Hampton Road, Teddington TW11 0LW, U.K.ORCID 0000-0001-9222-5722
Gustavo F TrindadeChemical and Biological Sciences Department, National Physical Laboratory, Hampton Road, Teddington TW11 0LW, U.K.ORCID 0000-0001-6998-814X
David J H CantChemical and Biological Sciences Department, National Physical Laboratory, Hampton Road, Teddington TW11 0LW, U.K.ORCID 0000-0002-4247-5739
Yiwen PeiChemical and Biological Sciences Department, National Physical Laboratory, Hampton Road, Teddington TW11 0LW, U.K.ORCID 0000-0001-6976-5560
Pawan DulalaVaxziPen Limited, Milton Park, Abingdon, Oxfordshire OX14 4SA, U.K.
Ali Al-KhattawiSchool of Pharmacy, Aston University, Birmingham B4 7ET, U.K.ORCID 0000-0002-2498-2817

Funding

Biotechnology and Biological Sciences Research Council (BBSRC) BB/T00746X/1
6 · The paper itself

Abstract

Spray drying is one of the leading manufacturing methods for active pharmaceutical ingredients (APIs) owing to its rapid, single-step, and cost-effective nature. It also has the capacity to generate microspheres capable of controlled release of APIs including biomolecules and vaccines. However, one of the key challenges of spray-dried formulations especially with poly(lactic-

Indexed as

MicrospheresParticle SizePolylactic Acid-Polyglycolic Acid CopolymerSerum Albumin, BovineAnimalsCattleChemistry, PharmaceuticalDelayed-Action PreparationsDesiccationDrug CompoundingDrug LiberationKineticsLactic AcidSpray DryingDelayed-Action PreparationsLactic AcidPolylactic Acid-Polyglycolic Acid CopolymerSerum Albumin, Bovineburst releasechemical depth profilingPLGA microspheresspray dryingsurface analysis

Identifiers

PMID39454183
PMCPMC11615953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.