Evidence map›Paper›PMID 39453916›Full record

ArticleACS applied materials & interfaces2024

Developing a High-Throughput Platform for the Discovery of Sustainable Antibacterial Materials.

Krzysztof Wieczerzak, Fedor F Klimashin, Amit Sharma, Stefanie Altenried, Katharina Maniura-Weber, Qun Ren, Johann Michler

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Krzysztof WieczerzakLaboratory for Mechanics of Materials and Nanostructures, Empa, Swiss Federal Laboratories for Materials Science and Technology, CH-3602 Thun, Switzerland.ORCID 0000-0001-9976-7591
Fedor F KlimashinLaboratory for Mechanics of Materials and Nanostructures, Empa, Swiss Federal Laboratories for Materials Science and Technology, CH-3602 Thun, Switzerland.ORCID 0000-0002-2152-7165
Amit SharmaLaboratory for Mechanics of Materials and Nanostructures, Empa, Swiss Federal Laboratories for Materials Science and Technology, CH-3602 Thun, Switzerland.
Stefanie AltenriedLaboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland.
Katharina Maniura-WeberLaboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland.ORCID 0000-0001-7895-3563
Qun RenLaboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland.ORCID 0000-0003-0627-761X
Johann MichlerLaboratory for Mechanics of Materials and Nanostructures, Empa, Swiss Federal Laboratories for Materials Science and Technology, CH-3602 Thun, Switzerland.ORCID 0000-0001-8860-4068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Healthcare-associated infections (HCAIs) pose a significant global health challenge, exacerbated by the rising threat of antimicrobial resistance (AMR). This study introduces a high-throughput platform designed to identify sustainable antibacterial surfaces, exemplified by a copper-silver-zirconium (CuAgZr) alloy library. Utilizing combinatorial synthesis and advanced characterization techniques, material libraries (MatLibs) are generated and evaluated to rapidly screen diverse alloy compositions. The results demonstrate the ability to reproducibly create alloys with significant antimicrobial properties and high hardness, making them suitable for biomedical applications. The study highlights the critical role of compositional precision in developing materials that balance mechanical strength with antibacterial efficacy. Additionally, this approach ensures significant cost-effectiveness, facilitating the identification of economically viable alloy compositions. This research underscores the potential of high-throughput materials science to expedite the discovery of sustainable solutions for reducing HCAIs and addressing AMR, signaling a leap forward in sustainable healthcare material development.

Indexed as

AlloysAnti-Bacterial AgentsCopperSilverZirconiumEscherichia coliHigh-Throughput Screening AssaysMicrobial Sensitivity TestsStaphylococcus aureusAlloysAnti-Bacterial AgentsCopperSilverZirconiumantimicrobial resistancehealthcare-associated infectionshigh-throughput characterizationmaterial librarymechanical propertiessustainable antimicrobial surfaces

Identifiers

PMID39453916
PMCPMC11551899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.